Brain morphologic abnormalities in migraine patients: an observational study
Background: Migraine is a common neurological disorder characterized by a complex physiopathology. We assessed brain morphologic differences in migraine and the possible pathogenetic mechanism underlying this disease.
Methods: We analyzed brain morphologic images of migraine patients, 14 with aura (MwA) [the mean (SD) age was 42.36 (2.95) years (range, 37-47)] and 14 without aura (MwoA) [the mean (SD) age was 43.5 (3.25) years (range, 39-50)] during episodic attack compared with health subjects balanced (HS) [the mean (SD) age was 42.5 (5.17) years (range, 34-51)]. All subjects underwent a Magnetic Resonance Imaging (MRI) examination with a scanner operating at 3.0 T and voxel based morphometry (VBM) approach was used to examine the gray matter volume (GMV). The statistical analysis to compare clinicl characteristics was performed using unpaired t-test an one-way Anova. Results: Total cerebral GMV showed a significant difference between MwA and HS (p=0.02), and between MwoA and HS (p=0.003). In addition, not significative differences were found between MwA and MwoA groups (p=0.17). We found three clusters of regions which showed significant GMV reduction in MwA compared with MwoA. MwA subjects showed a less of GMV in 4 clusters if compared with HS, and MwoA subjects showed a less of GMV in 3 clusters if compared with HS. We observed that MwA and MwoA patients had a significant reduction of GMV in the frontal and temporal lobe and the cerebellum, if compared to HS. The bilateral fusiform gyrus and the cingulate gyrus were increase in MwoA patients compared with HS.
Conclusion: Our findings could provide a approach to understand possible differences in the pathogenesis of two type of migraine.
Figure 1
Posted 14 Apr, 2020
On 08 Apr, 2020
On 07 Apr, 2020
On 07 Apr, 2020
Received 01 Mar, 2020
On 01 Mar, 2020
Received 28 Feb, 2020
On 17 Feb, 2020
On 16 Feb, 2020
On 13 Feb, 2020
Invitations sent on 13 Feb, 2020
On 12 Feb, 2020
On 12 Feb, 2020
On 12 Feb, 2020
Brain morphologic abnormalities in migraine patients: an observational study
Posted 14 Apr, 2020
On 08 Apr, 2020
On 07 Apr, 2020
On 07 Apr, 2020
Received 01 Mar, 2020
On 01 Mar, 2020
Received 28 Feb, 2020
On 17 Feb, 2020
On 16 Feb, 2020
On 13 Feb, 2020
Invitations sent on 13 Feb, 2020
On 12 Feb, 2020
On 12 Feb, 2020
On 12 Feb, 2020
Background: Migraine is a common neurological disorder characterized by a complex physiopathology. We assessed brain morphologic differences in migraine and the possible pathogenetic mechanism underlying this disease.
Methods: We analyzed brain morphologic images of migraine patients, 14 with aura (MwA) [the mean (SD) age was 42.36 (2.95) years (range, 37-47)] and 14 without aura (MwoA) [the mean (SD) age was 43.5 (3.25) years (range, 39-50)] during episodic attack compared with health subjects balanced (HS) [the mean (SD) age was 42.5 (5.17) years (range, 34-51)]. All subjects underwent a Magnetic Resonance Imaging (MRI) examination with a scanner operating at 3.0 T and voxel based morphometry (VBM) approach was used to examine the gray matter volume (GMV). The statistical analysis to compare clinicl characteristics was performed using unpaired t-test an one-way Anova. Results: Total cerebral GMV showed a significant difference between MwA and HS (p=0.02), and between MwoA and HS (p=0.003). In addition, not significative differences were found between MwA and MwoA groups (p=0.17). We found three clusters of regions which showed significant GMV reduction in MwA compared with MwoA. MwA subjects showed a less of GMV in 4 clusters if compared with HS, and MwoA subjects showed a less of GMV in 3 clusters if compared with HS. We observed that MwA and MwoA patients had a significant reduction of GMV in the frontal and temporal lobe and the cerebellum, if compared to HS. The bilateral fusiform gyrus and the cingulate gyrus were increase in MwoA patients compared with HS.
Conclusion: Our findings could provide a approach to understand possible differences in the pathogenesis of two type of migraine.
Figure 1