Ethics approval and consent to participate
The study was approved by the Ethics Committee of Peking University Shenzhen Hospital (No.2020013). Participants were informed to participate in the trial voluntarily with written informed consent.
Consent for publication
Dr. Liang Gao is a member of the editorial board of BMC Musculoskeletal Disorders. The other authors declare that they have no competing interests.
Guoqing Li and Fei Yu participated in the design and prepared the manuscript, who contributed equally to this work and listed as cooperated first authors. Jian Weng, Ao Xiong, and Deli Wang participated in the critical revision of the manuscript. Su Liu, Tiantian Qi, Haotian Qin, Yixiao Chen, and Fangxi Wang collected and inputed the data. Guoqing Li participated in execution and analysis of the work presented. Liang Gao and Hui Zeng participated in the design, participated in the critical revision of the manuscript, and reviewed the ﬁnal manuscript, who contributed equally to this work and listed as corresponding authors.
The authors sincerely acknowledge the entire staff of the Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, who offered their assistance throughout the course of this study. Moreover, we appreciated it very much for Chang Xu, Xiaoyan Huang and Jing Li, who helped us in statistics analysis.
1 Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, People’s Republic of China, 518036. 2 National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, People’s Republic of China, 518036. 3 Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrberger Strasse, Building 37, D-66421 Homburg, Saarland, Germany.
This study was supported by grants from Shenzhen Key Medical Subject (No.SZXK023), Shenzhen “San-Ming” Project of Medicine (No.SZSM201612092), National Natural Science Foundation of China (No. 82172432 and 82001319), Guangdong Basic and Applied Basic Research Foundation (No.2019A1515011290 and No.2019A1515110983), Bethune Charitable Foundation and CSPC Osteoporosis Research Foundation Project (No.G-X-2020-1107-21), Shenzhen Research and Development Project (No.JCYJ20170307111755218, No.JCYJ20190809110807421, and JCYJ20210318153832004), Scientific research project of health and family planning system in Shenzhen (No.SZXJ2018077), Sustainable development project of Science and Technology in Shenzhen (No.KCXFZ20201221173411031), and Shenzhen High-level Hospital Construction Fund.
Availability of data and materials
Data are available from the authors upon reasonable request with the permission of Department of bone and joint in Peking University Shenzhen Hospital.