Through the technology developed by us, we can use algorithms and software for distance automated monitoring of the prenosological level of an individual health. This will allow us to optimize dispensary examinations of the population, ensure their necessary coverage, low-cost, operate continuously and when using modern algorithms for recognizing specified signs, it is intelligent. A condition needed for the implementation of the project is the assignment of the role of the correspondent, at least one in each family, which will oversee transmission and reception of personal electronic medical data to the population itself. At the same time, in order to minimize financial costs for the purchase of foreign medical gadgets, it is necessary to train the population to receive data on the morphological and functional indicators of the body using non-invasive and generally accessible methods and send them to the appropriate health center serving its territorial unit, using a personal mobile phone. The hardware and software provision of each such module requires the presence in each family of at least one unit of mobile communications with the necessary parameters and connected to the Internet. For all, such mobile communications will be equipped with the correct software and the interfaces for exchanging information with the server of our health center. This will make it possible to put into practice the principle - a mobile patient - a virtual doctor. By creating an individual monitoring of the prenosological level of health based on this principle, and organizing its modular functioning for a specific region of the population of a given geographical area with the involvement of prevention doctors responsible for this area of the family clinic, significant results can be achieved in preventing risk factors, and maintaining of the health of the population. As a module, we have taken the conventional eastern public structure - citizens' self-government - “mahalla”, an association of citizens created in their place of residence and functioning in accordance with the special law of the Republic of Uzbekistan. The described modular principle and mechanism for distance monitoring of the prenosological level of individual health, as a pilot project, we are implementing among the student of the Ferghana branch of the Tashkent Medical Academy - as a structural unit. The architecture and diagram of the information and analytical remote technology developed by us is presented in Fig. 1. In the initial version of the technological project , using the effective non-invasive methods for assessing the level of health described in the literature [5-10], we envisage implementation, based on individual indicators of students, and medical knowledge bases (formed from literature data on quantitative and qualitative criteria for evaluating certain indicators of body health level), remote individual assessment: adaptive potential and functional reserves of the body. State of autonomic regulation of the cardiovascular system, a prediction of the possibility of developing arterial hypertension, as well as a number of anthropometric and morphofunctional indices, allowing to evaluate the prenosological level of their somatic health.
The following assessment of physical status was obtained by the general method of somatometry with the calculation of evaluating indices: average values of the Ketle index (IR). An increased Ketle index is considered as one of the risk factors for arterial hypertension. Based on anthropometric data, the Piñe indices were calculated, according to which the somatotypes of the examined were determined.
The simplified algorithm of prenosological diagnosis describes well the functional states were a stable relationship between the main physiological parameters is preserved. According to the study of the functional status, the value of the indicators of physiological reserves of the respiratory system, of the Stange and Gencha samples was obtained. The data obtained reflect the power levels and the efficiency of aerobic energy production. To determine resistance to hypoxia, an index - the ratio of resting heart rate to inspiration apnea duration was calculated. One of the informative prenosological integral indicators reflecting the features of adaptive-adaptive reactions of the body in a healthy population of people is the type of self-regulation of blood circulation (TSBC). Based on an integrated assessment of the cardiovascular system, analysis of the ratio of the cardiac and vascular components of central hemodynamics N.I. Arinchin et al. Established the existence of three types of TSBCs in healthy people: cardiac, vascular, and cardiovascular . Determination of TSBC makes it possible to assess the level of tension in the regulation of the cardiovascular system. It is worth mentioning that the prospect of the transition of the prenosological state into the disease is determined by the adaptive capabilities of the body and, in particular, the regulation of physiological functions. Therefore, an important position in promising medical control systems should be taken by information technologies aimed at assessing the state of regulatory systems, since, as already mentioned, it is the over strain of regulatory mechanisms, as well as the associated decrease in functional reserves, that is one of the main risk factors for the development of diseases . The cardiovascular system, as a sensitive indicator of adaptive reactions of the whole organism, is the first to respond to all fluctuations in environmental conditions, it is a regulator of the internal body environment, maintaining homeostasis of its organs and systems through their adequate blood supply. In this regard, as a criterion of the adaptive capabilities of the organism R. M. Baevsky, A. P. Bersenev proposed to determine the index of functional changes (IFCh) , IFCh = 0.011HR + 0.014SAP + 0.008DAP + 0.014A + 0.009BW-0.009H-0.27, for the calculation of which only data on the heart rate (HR) are required, diastolic and systolic arterial pressure (DAP, SAP), height (H), body weight (BW) and age (A) obtained by non-aggressive methods. Based on the obtained IFCh value, each individual, depending on the degree of adaptation, can be assigned to one of four groups (satisfactory adaptation, tension of adaptation mechanisms, unsatisfactory adaptation, failure of adaptation): the higher the conditional score of the IFCh, the higher the likelihood of pathological deviations. Pre-medical screening, based on the evaluation of IFCh, with all its simplicity, provides a systematic approach to assessing the functional state of the circulatory system as an indicator of the adaptive capabilities of the body as a whole. The level of functional reserves, which we monitored according to the Kournikova approach, is an independent prenosological indicator of health, adequately reflecting the state of the body's adaptation systems to adverse environmental influences . Moreover, it is the most sensitive and dynamic criterion that allows identifying priority risk factors.
We should point out that the protocol of examination depends on the purpose of the prenosological examinations and may vary depending on the tasks and the volume of the studies. The software for evaluating the results of analysis and forming conclusions is the most important and a crucial part of the technology of prenosological studies. The issues of constructing algorithms for recognition various classes of prenosological conditions are fundamental in solving the problems of automation of mass prenosological diagnostics associated with the examination of large populations. Here, the selection of the most informative indicators is necessary and their minimization with the development of optimal decision rules. The algorithm, as an exact instruction of execution order for a certain group of actions or operations, may lead to the solution of the task, but it should construct on scientifically based criteria. In this case, in terms of algorithms for prenosological diagnostics, we are referring to physiological criteria that we have accumulated in the knowledge base of the analytical unit of our system. At the same time, we have taken into account that various physiological indicators used in assessing the functional state have different information content and accordingly make an unequal contribution to obtaining the final result in the formulation of the prenosological diagnosis. Assessing the level of human health by individuals, even if informative, indicators do not give a holistic view. The integration of separate parameters is necessary in order to obtain a total quantitative indicator (index) of the health. This gave a reason to introduce the idea of a prenosological syndrome as an indicator of a complex of certain deviations of different indicators. To assess the integral level of health, we used the Apanasenko method, where a similar approach was implemented using 5 indicators of the body . The listed factors, adequately characterizing the level of the prenosological state of the body, are calculated on the basis of data determined by non-invasive and comfortable methods, which are important for prenosological monitoring of the health of individuals. Algorithms for the analysis of recorded indicators, including morphofunctional development, functional reserves and the condition of leading organs and systems, using factor analysis, provide a clear relationship between morphofunctional development indicators and health status, and the determination of the individual's internal health structure. This function is performed by using the algorithm developed by us and the software for their automated computer implementation which allows us to assign each object of investigation to one of the following categories and from the corresponding population databases:
1-category: contingent with a high level of healthy individuals that do not require the implementation of any preventive measures - the contingent of the green folder base;
2-category: people with risk factors for health - the contingent of the base of the yellow folder;
3-category: people with one or more chronic diseases - the contingent of the red folder base.
We should point out that to identify each monitoring object in the database and in all information registers, they will be assigned a 15-digit single individual number by which you can set its address and status in the family, and, if necessary, convert it to information according to its passport data. Thus, according to the goal, a comprehensive monitoring of the physical, functional and clinical-somatic status of population health indicators is carried out. It provides for the implementation of the functions of prenosological diagnosis, screening and control, namely:
Comprehensive prenosological examination of citizens, including anthropometric and other morphological, and functional indicators.
Screening, assessment of the level of somatic health, functional and adaptive reserves of the body, rapid assessment of cardiovascular, and autonomic system, assessment of complex indicators of the function of the respiratory system.
Based on the results of the surveys, an assessment can be conducted to assess the level of risk of onset of certain diseases.