Punicalagin is the most bioactive polyphenols of pomegranate with high antioxidant, FRS activity. It has the potential to cure different ailments related to the CVS system. The current research work was envisioned to predict the targeting efficiency of punicalagin (PG) nanoparticles to the macrophages, more specifically to bone marrow macrophages. For this, we selected mannose decorated PLGA-punicalagin nanoparticles (Mn-PLGA-PG) and before formulating this nanocarrier in laboratory settings, we predict the targeting efficiency of this nanocarrier by in-silico analysis. Authors initiated in-silico analysis on macrophage mannose receptor to be acquainted with the binding affinity, the interaction of PG based nanocarrier (MnPLGA-PG) to this receptor. In-silico docking studies of macrophage mannose receptor and PG showed binding interaction on its surface with a docking score of -4.00. PG interacts with hydrogen bonds to the charged residue ASP668 and GLY666 and polar residue GLN760 residue of Mn receptor. Mannose with a docking score of -5.811 and interacting with four hydrogen bonds to the mannose receptor of macrophage with two negatively charged residues GLU706, GLU719 also with two hydrophobic residues VAL716, PHE708. And in PLGA, it showed a - 4.334 docking score and interacts with three hydrogen bonds, LYS739 (positively charged), HIS692 (polar), and LEU694 (hydrophobic)..In trajectory analysis, while stabilizing the structure till 100ns the complex RMSD of macrophage, Mn receptor-PG found within the range of 4.6 Å. Initial fluctuations in RMSD noticed to 4.95 Å at 20ns which started stabilizing after words with timescale. In the total of 100ns, initially up to 40ns the PG (ligand) deviated to 1.2Å. After 40ns, it was noted that the ligand RMSD was almost constant and started stabilizing with 1.03Å at 100ns. Findings depict that this nanocarrier could be a promising lead molecule to regulate the incidence of drug induced neutropenia.