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Research Article
Retinal Sensitivity and Ganglion Cell-Related Retinal Layer Thickness in the Normal Aging Process
Makoto Araie
Kanto Central Hospital of the Mutual Aid Association of Public School Teachers
Corresponding Author
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Aging-associated changes in visual field (VF) sensitivity were compared prospectively and longitudinally with the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and macular ganglion cell-inner plexiform layer thickness (GCIPLT) changes in the corresponding retinal areas of the same eyes (72 eyes of 37 normal Japanese subjects; mean age, 51.3 years). The Humphrey Field Analyzer 24-2 test (HFA 24-2) and spectral-domain optical coherence tomography (SD-OCT) measurements of the cpRNFLT and GCIPLT in a 0.6-mm-diameter circle corresponding to the four central points of HFA 24-2 adjusted for retinal ganglion cell displacement (GCIPLT4TestPoints) were performed every 3 months for 3 years. The tiem changes of the mean sensitivity over the entire field (VFmean) and the four central points (VF4TestPoints), cpRNFLT, and GCIPLT4TestPoints were analyzed using a linear mixed model. The aging-associated decline rates of VFmean and VF4TestPoins were 0.12 and 0.19 decibels/year (p<0.001), which significantly accelerated with increased subjects’ age (0.009 and 0.010 decibels/year, p<0.001, respectively) without changes in the ocular media. Those of the CpRNFLT and GCIPLT4TestPoints were not significant in both (p>0.114), but significantly accelerated with increased subjects’ age (0.021 and 0.010 mm/year, p=0.001 and 0.004, respectively). These results have implications in studying physiological aging- or desease-related changes in these parameters.
Keywords
visual field (VF), circumpapillary retinal nerve fiber layer thickness (cpRNFLT), spectral-domain optical coherence tomography (SD-OCT)
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Received 18 Feb, 2021
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Reviewer #2 agreed
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Reviewer #3 agreed
On 26 Jan, 2021
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Retinal Sensitivity and Ganglion Cell-Related Retinal Layer Thickness in the Normal Aging Process
Makoto Araie
Kanto Central Hospital of the Mutual Aid Association of Public School Teachers
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 21 Jan, 2021
No community comments so far
Review #1 received
Received 18 Feb, 2021
Reviewer #1 agreed
On 26 Jan, 2021
Reviewer #2 agreed
On 26 Jan, 2021
Reviewer #3 agreed
On 26 Jan, 2021
Reviewers invited
Invitations sent on 25 Jan, 2021
Editor assigned
On 25 Jan, 2021
Editor invited
On 20 Jan, 2021
Submission checks complete
On 20 Jan, 2021
First submitted
On 18 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Aging-associated changes in visual field (VF) sensitivity were compared prospectively and longitudinally with the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and macular ganglion cell-inner plexiform layer thickness (GCIPLT) changes in the corresponding retinal areas of the same eyes (72 eyes of 37 normal Japanese subjects; mean age, 51.3 years). The Humphrey Field Analyzer 24-2 test (HFA 24-2) and spectral-domain optical coherence tomography (SD-OCT) measurements of the cpRNFLT and GCIPLT in a 0.6-mm-diameter circle corresponding to the four central points of HFA 24-2 adjusted for retinal ganglion cell displacement (GCIPLT4TestPoints) were performed every 3 months for 3 years. The tiem changes of the mean sensitivity over the entire field (VFmean) and the four central points (VF4TestPoints), cpRNFLT, and GCIPLT4TestPoints were analyzed using a linear mixed model. The aging-associated decline rates of VFmean and VF4TestPoins were 0.12 and 0.19 decibels/year (p<0.001), which significantly accelerated with increased subjects’ age (0.009 and 0.010 decibels/year, p<0.001, respectively) without changes in the ocular media. Those of the CpRNFLT and GCIPLT4TestPoints were not significant in both (p>0.114), but significantly accelerated with increased subjects’ age (0.021 and 0.010 mm/year, p=0.001 and 0.004, respectively). These results have implications in studying physiological aging- or desease-related changes in these parameters.
Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the latest manuscript can be downloaded and accessed as a PDF.
Due to technical limitations, table 1 to 5 is only available as a download in the Supplemental Files section.