Table 1 Criteria for clinical diagnosis of the MetS
Measure
|
Categorical cut points
|
Elevated waist circumference+
|
≥80cm
|
Elevated triglycerides
|
≥1.7mmol/L
|
Low-HDL
|
<1.3mmol/L
|
Elevated blood pressure
|
Systolic ≥130 and/or diastolic ≥85mmHg
|
Elevated fasting glucose
|
≥5.56mmol/L
|
Abbreviations: MetS, metabolic syndrome
+Based on current recommended waist circumference thresholds for abdominal obesity by organization[1].
Table 2 Demographic characteristics and metabolic parameters of included patients
Variables (n=291)
|
Values
|
Age (yr)
|
|
Mean±SD
|
57.61±11.18
|
BMI (kg/m2)
|
|
<30
|
239 (82.1)
|
≥30
|
52 (17.9)
|
History of diabetes
|
|
Yes
|
69 (23.7)
|
No
|
222 (76.3)
|
Elevated blood pressure
|
|
Yes
|
115 (39.5)
|
No
|
176 (60.5)
|
Menopause
|
|
Yes
|
194 (66.7)
|
No
|
97 (33.3)
|
FIGO-Staging
|
|
Early (FIGO I-II)
|
239 (82.1)
|
Advanced (FIGO III-IV)
|
52 (17.9)
|
Histologic of subtype
|
|
EEC
|
268 (92.1)
|
NEEC
|
23 (7.9)
|
Metabolic parameters
|
|
FPG (mmol/L)
|
5.96±2.05
|
TG (mmol/L)
|
1.64±1.12
|
HDL (mmol/L)
|
1.23±0.09
|
Large waist circumference
|
|
≥80
|
54(18.6)
|
<80
|
237(81.4)
|
MetS
|
|
Yes
|
81(27.8)
|
No
|
210(72.2)
|
Serum magnesium concentration
|
|
Total serum magnesium (mmol/L)
|
0.93±0.08
|
Values are presented as number (%) or Mean±SD.
Abbreviations: BMI, body mass index; FIGO, International Federation of Gynecology and Obstetrics; EEC, endometrioid endometrial carcinoma; NEEC, non-endometrioid endometrial carcinoma; FPG, fasting plasma glucose; TG, triglyceride; HDL, high-density lipoprotein; MetS, metabolic syndrome; SD, standard deviation
Table 3 Comparison of serum magnesium in patients with different clinical characteristic
|
Total serum magnesium (mmol/L)
|
P-value
|
Age
|
|
|
<60
|
0.92±0.07
|
0.155
|
≥66
|
0.93±0.08
|
BMI
|
|
|
<30
|
0.93±0.08
|
0.823
|
≥30
|
0.93±0.08
|
History of diabetes
|
|
|
Yes
|
0.90±0.09
|
0.005*
|
NO
|
0.93±0.07
|
Elevated blood pressure
|
|
|
Yes
|
0.93±0.08
|
0.821
|
NO
|
0.93±0.08
|
Menopause
|
|
|
Yes
|
0.91±0.07
|
0.018*
|
No
|
0.94±0.08
|
FIGO-Staging
|
|
|
Early
|
0.94±0.08
|
0.110
|
Advanced
|
0.91±0.08
|
Histologic of subtype
|
|
|
EEC
|
0.93±0.08
|
0.460
|
NEEC
|
0.92±0.09
|
MetS
|
|
|
YES
|
0.91±0.08
|
0.813
|
NO
|
0.93±0.08
|
Values are presented as Mean±SD.
Abbreviations: BMI, body mass index; FIGO, International Federation of Gynecology and Obstetrics; EEC, endometrioid endometrial carcinoma; NEEC, non-endometrioid endometrial carcinoma; MetS, metabolic syndrome; SD, standard deviation. *p<0.05
Table 4 Differences of clinical characteristic and metabolic parameters in different serum magnesium concentration.
|
Serum magnesium concentration
|
|
P-value
|
<0.7mmol/L
|
0.7mmol/L≤and≤1.1mmol/L
|
>1.1mmol/L
|
Age
|
Mean±SD
|
58.56±7.82
|
56.98±11.63
|
57.62±8.01
|
0.822
|
BMI
|
Mean±SD
|
25.10±4.31
|
24.41±3.93
|
24.33±3.12
|
0.014*
|
History of diabetes
|
YES
|
10 (55.6)
|
55 (22.5)
|
6 (20.7)
|
0.006*
|
NO
|
8 (44.4)
|
189 (77.5)
|
23 (79.3)
|
Menopause
|
YES
|
13 (72.2)
|
158 (64.8)
|
22 (75.9)
|
0.421
|
NO
|
5 (27.8)
|
86 (35.2)
|
7 (24.1)
|
FIGO-staging
|
Early
|
14 (77.8)
|
199 (81.2)
|
22 (75.9)
|
0.722
|
Advanced
|
4 (22.2)
|
45 (18.8)
|
7 (24.1)
|
Histologic of subtype
|
EEC
|
15 (83.3)
|
219 (89.8)
|
25 (86.2)
|
0.618
|
NEEC
|
3 (16.7)
|
25 (10.2)
|
4 (13.8)
|
Elevated blood pressure
|
YES
|
8 (44.4)
|
98 (40.2)
|
8 (27.6)
|
0.378
|
NO
|
10 (65.6)
|
146 (59.8)
|
21 (72.4)
|
TG
|
Mean±SD
|
2.29±2.95
|
1.62±0.91
|
1.47±0.60
|
0.046*
|
Hypertriglyceridemia
|
6 (33.3)
|
81 (33.2)
|
7 (24.1)
|
0.612
|
Non-hypertriglyceridemia
|
12 (66.7)
|
163 (66.8)
|
22 (75.9)
|
FPG
|
Mean±SD
|
6.54±2.46
|
5.95±1.89
|
5.82±2.90
|
0.476
|
Hyperglycaemia
|
13 (72.2)
|
98 (40.2)
|
8 (27.6)
|
0.026
|
Non-hyperglycaemia
|
5 (27.8)
|
146 (59.8)
|
21 (72.4)
|
HDL
|
Mean±SD
|
1.19±0.36
|
1.23±0.31
|
1.20±0.28
|
0.877
|
Low-HDL
|
13 (72.2)
|
169 (69.3)
|
20 (68.9)
|
0.815
|
Non-low-HDL
|
5 (27.8)
|
75 (30.7)
|
9 (31.1)
|
Large waist
circumference
|
YES
|
4 (22.2)
|
45 (18.4)
|
3 (10.3)
|
0.287
|
NO
|
14 (77.8)
|
199 (81.6)
|
26 (89.7)
|
MetS
|
YES
|
7 (38.9)
|
68 (27.9)
|
4 (13.8)
|
0.140
|
NO
|
11 (61.1)
|
176 (72.1)
|
25 (86.2)
|
Values are presented as number (%) or Mean±SD.
Abbreviations: BMI, body mass index; FIGO, International Federation of Gynecology and Obstetrics; EEC, endometrioid endometrial carcinoma; NEEC, non-endometrioid endometrial carcinoma; TG, triglyceride; FPG, fasting plasma glucose; HDL, high-density lipoprotein; MetS, metabolic syndrome; SD, standard deviation. *p<0.05
Table 5 clinical characteristic according to criteria of metabolic syndrome
Table 6 The correlation analyses between serum magnesium concentration and MetS criteria
MetS Criteria
|
Serum magnesium concentration (mmol/L)
|
r
|
P-value
|
0
|
1.01±0.05
|
-0.201£
|
<0.001£*
|
1
|
0.94±0.08
|
2
|
0.92±0.08
|
3
|
0.92±0.07
|
4
|
0.88±0.12
|
5
|
0.91±0.09
|
Values are expressed as Mean±SD.
£Spearman correlation coefficients between serum magnesium and MetS criteria.
Abbreviations: MetS, metabolic syndrome. *p<0.05
Table 7 Correlation in EC patients of serum magnesium levels and metabolic parameters and MetS
|
|
FPG
|
TG
|
HDL
|
LWC
|
EBP
|
MetS
|
Total serum magnesium (mmol/L)
|
r
|
-0.078+
|
-0.109+
|
0.0787+
|
-0.151£
|
-0.028£
|
-0.120£
|
p
|
0.181+
|
0.066+
|
0.143+
|
0.009£*
|
0.627£
|
0.038£*
|
r
|
-0.075§
|
-0.147§
|
0.076§
|
-0.133§
|
0.003§
|
-0.101§
|
p
|
0.202§
|
0.025§*
|
0.200§
|
0.023§*
|
0.960§
|
0.013§*
|
Abbreviations: FPG, fasting plasma glucose; TG, triglyceride; HDL, high-density lipoprotein; LWC: large waist circumference; EBP: Elevated blood pressure; MetS: Metabolic syndrome.
+Pearson correlation test; £Spearman correlation test; §Partial correlation test, adjusted for history of diabetes and menopause; *p<0.05.
1Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al.(2009). Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120(16):1640-5. http://doi.org/.10.1161/circulationaha.109.192644