Many environmental factors and stresses influence plant growth and development. High salt stress is expected to have a damaging effect on more than 50% of fully arable land by 2050. Understanding the response of plants to excessive use of nitrogen fertilisers and salt stress is vital for increasing crop productivity. However, the effect of excessive nitrate application on plant growth is controversial and not well-understood; therefore, we investigated the effect of a high nitrate supply and high salt stress on plant growth performance. We showed that abi5-7 plants exhibited tolerance to adverse environmental conditions of high nitrate and high salinity stress. Particularly, abi5-7 plants showed lower endogenous nitric oxide levels than Col-0 plants because of their lower nitrate reductase activity, resulting from the decreased transcript levels of NIA2 , a gene encodes nitrate reductase. The supply of excess nitrate reduced the plant's salt stress tolerance, in which nitric oxide appeared to play a crucial role. Therefore, discovering regulators, such as ABI5, that can regulate nitrate reductase activity and understanding the molecular functions of these regulators are important for implementing gene-editing techniques to modulate transcription factor activities, leading to the optimal accumulation of nitric oxide to increase the productivity of crops exposed to various stress environments.