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Research Article
Yuqian Zhou
Second Xiangya Hospital of Central South University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives: Growing evidence suggests that aberrant expression of Karyopherin alpha (KPNA) has been involved in the tumor progression of various cancer types. However, the differential expression patterns and prognostic value of the seven KPNA subtypes remain to be investigated. Hence the transcriptional and survival data of KPNAs in patients with pancreatic adenocarcinoma (PAAD) were analyzed.
Methods: Transcriptional and survival data related to KPNA expression in patients with PAAD were derived through ONCOMINE, Gene Expression Profiling Interactive Analysis 2, and Human protein atlas databases. The DNA alteration for KPNAs came from The Cancer Genome Atlas and c-BioPortal. The prognostic value analysis was performed with Kaplan–Meier Plotter. Gene functional enrichment analyses were conducted in database LinkedOmics and Metascape.
Results: The mRNA expression levels of KPNA1-4, 6,7 were found significantly upregulated in pancreatic cancer tissues than in normal pancreas tissues, whereas the aberrant expression level of KPNA5 was no more significant in the former than in the latter. KPNA1, 4, and 7 were associated with tumor stage or grade of PAAD. Nevertheless, the obvious association with clinical outcomes was identified only in the aberrant expression of KPNA4. Further gene functional exploration about KPNA4 displayed KPNA4 strongly associated with adherens junction and tumor metastasis in PAAD.
Conclusion: Our findings suggested that KPNA4 might be a potential diagnostic and a new biomarker of prognosis for patients with pancreatic adenocarcinoma.
Keywords
pancreatic adenocarcinoma, KPNA, transcriptional, prognostic, biomarker
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No competing interests reported.
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CURRENT STATUS: Under Review
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Received 22 Apr, 2021
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On 22 Apr, 2021
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On 21 Apr, 2021
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Subject Areas
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This preprint is under consideration at BMC Medical Genomics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Yuqian Zhou
Second Xiangya Hospital of Central South University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 01 Feb, 2021
No community comments so far
Reviews received
Received 22 Apr, 2021
Reviewers agreed
On 22 Apr, 2021
Reviewers agreed
On 21 Apr, 2021
Reviewers invited
Invitations sent on 04 Feb, 2021
Editor assigned
On 27 Jan, 2021
Editor invited
On 27 Jan, 2021
Submission checks complete
On 27 Jan, 2021
First submitted
On 20 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Epigenetics & Genomics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives: Growing evidence suggests that aberrant expression of Karyopherin alpha (KPNA) has been involved in the tumor progression of various cancer types. However, the differential expression patterns and prognostic value of the seven KPNA subtypes remain to be investigated. Hence the transcriptional and survival data of KPNAs in patients with pancreatic adenocarcinoma (PAAD) were analyzed.
Methods: Transcriptional and survival data related to KPNA expression in patients with PAAD were derived through ONCOMINE, Gene Expression Profiling Interactive Analysis 2, and Human protein atlas databases. The DNA alteration for KPNAs came from The Cancer Genome Atlas and c-BioPortal. The prognostic value analysis was performed with Kaplan–Meier Plotter. Gene functional enrichment analyses were conducted in database LinkedOmics and Metascape.
Results: The mRNA expression levels of KPNA1-4, 6,7 were found significantly upregulated in pancreatic cancer tissues than in normal pancreas tissues, whereas the aberrant expression level of KPNA5 was no more significant in the former than in the latter. KPNA1, 4, and 7 were associated with tumor stage or grade of PAAD. Nevertheless, the obvious association with clinical outcomes was identified only in the aberrant expression of KPNA4. Further gene functional exploration about KPNA4 displayed KPNA4 strongly associated with adherens junction and tumor metastasis in PAAD.
Conclusion: Our findings suggested that KPNA4 might be a potential diagnostic and a new biomarker of prognosis for patients with pancreatic adenocarcinoma.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
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