Table1 shows the demographical data of participants. There was no difference in age, education and sex between groups. AD group has significant lower MMSE score as expected and AD group has more APOE ε4 carriers than other groups.
Local correlation between rCBF and subcortical volume
After implementing controlled correlation we found a significant local correlation between rCBF and subcortical volume in groups. In AD group we only find correlation in 4th ventricle, however in MCI the significant regions observed in 3th, 4th, left and right lateral ventricles, and Right nucleus accumbens (Tab2). Also there is correlation in Right pallidum, Right vessel, and White matter of left hemisphere cerebellum in CN group (Tab2).
Local correlation between rCBF and thickness
Across all AD patients we only find negative correlation in two regions including posterior part of left middle frontal and caudal part of right anterior cingulate (Tab3). Pearson’s correlation showed a correlation between rCBF and thickness in widespread regions among MCI group (Tab3). This significant relation was observed in left entorhinal area, left and right lateral occipital, Left and right superior parietal lobule, Right inferior parietal lobule, Posterior part of right middle frontal, Right superior frontal, Right inferior temporal, Right pericalcarine, Right postcentral, Right precentral, and Rostral part of right anterior cingulate (Tab3). In healthy participants the correlation exist in Left entorhinal area and Rostral part of left anterior cingulate (Tab3).
Local correlation between rCBF and cortical volume
Results demonstrate the significant correlation between rCBF and cortical volume only in MCI and CN groups (Tab4). We found a wide positive correlation in left and right postcentral, left and right precentral, left and right precuneus, right precuneus, left and right posterior cingulate, caudal and rostral part of left anterior cingulate , right superior frontal, left and right superior parietal, right inferior parietal, left and right superior temporal, right transverse temporal, left and right inferior temporal, left middle temporal, left temporal, right lateral occipital, left and right supramarginal, right insula, left entorhinal, and right bankssts in MCI patients (Tab4). Significant results was fewer in CN group which involve left and right superior parietal, right supramarginal, left entorhinal, left fusiform, left medial orbital, anterior part of left middle frontal, left temporal, right inferior temporal, and rostral part of left anterior cingulate (Tab4). There is no considerable correlation in AD individuals.
Local correlation between rCBF and surface area
Investigating the local association between rCBF and surface area in our groups revealed that in AD patients, this correlation observed in left inferior temporal and isthmus of left cingulate (Tab5). As results described in Table5, significant correlations in MCI group similar to previous models was more than other groups (Tab5). rCBF and surface area was correlate in left and right precuneus, right superior and inferior parietal, right superior temporal, left and right transverse temporal, left inferior and middle temporal, left temporal pole, caudal and rostral part of left anterior cingulate, left posterior cingulate, left supramarginal, right middle orbital, right bankssts, and right fusiform in MCI patients (Tab5). Also in CN group, significant correlations observed in regions including right precentral, left and right superior parietal, left and right supramarginal, left fusiform, left and right lateral occipital, right inferior and middle temporal, and orbital part of left inferior frontal (Tab5).