The purpose of this pilot study was to examine the preliminary effectiveness and feasibility of a tailored MBPA intervention on well-being, stress, interoceptive sensibility, and objective physical activity (PA) in a sample of college students during COVID-19. Participants were 21 university students (81% were female). The study was conducted within an Interrupted Time-Series Design framework. Self-report data, well-being (WHO-5), stress (PSS-4), and interoceptive sensibility were collected at six time points. Objective PA data were assessed using a wrist-worn ActiGraph GT9X accelerometer over three 7-day periods, at baseline, mid-and postintervention. Mixed design Analysis of Variance (ANOVA) tests with repeated measures showed that participants’ time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA) was significantly higher during and at the end of the intervention compared to baseline (LPA [F (2, 36) = 11.9, P = .003, partial eta-squared = 0.39]; MVPA [F (2, 36) = 11.2, P < .001, partial eta-squared = 0.38]). It was found that participants’ subjective well-being main effect for time [F (5, 75) = 1.1, P = .363, partial eta-squared = 0.07], perceived stress [F (5, 75) = 1.2, P = .281, partial eta-squared = 0.44], and interoceptive sensibility [F (1.4, 19.0) = 2.8, P = .097, partial eta-squared = 0.18] did not change significantly; however, the results indicated positive trends. In conclusion, results indicate conducting a more extensive study. The MBPA intervention’s positive effects and trends promise to be a feasible intervention to increase PA among students in higher education.