Till presently wound dressing is an unmet contest amidst pharmaceutical and operational society. Indeed, chronic and post-traumatic wounds can be deadly in several situations since they manage to be settled effortlessly by renitent microorganisms like bacteria and germs. Diverse bandages were furnished to coat the wound superficies to be an appropriate hurdle against injury contagion [1, 2].
Native antibiotics can perform a significant function to avert and cure various dominant dermal pathogenic contagions such as regional superficial contagions owing to trauma, and abrasion. Linezolid is an antibacterial agent that is forcefully used for the treatment of complicated skin and skin structure infections (SSSIs), including diabetic foot infections (DFIs) without concomitant osteomyelitis averse to wound pathogens inclusive Methicillin-Resistant Staphylococcus aureus (MRSA) .
Linezolid was identified chemically as (S)-N-[[3-(3fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl] methyl] acetamide which meditated as the first member of the class of oxazolidinone antibiotics that performs by inhibiting the initiation of bacterial protein synthesis and terrific pharmacokinetic index [3, 4].
Latterly, antimicrobial systems based on bio-polymeric infrastructure are being inspected to remedy the impedance of antimicrobial troubles and ascertain a valid solution for the strengthening of the interaction between antibiotics and bacterial cell barriers.
It is renowned that naturally occurred sodium carboxymethyl cellulose (Na-CMC); is very hydrophilic (water affinity) due to the presence of numerous hydroxyl (-OH) and carboxyl (-COOH) groups. Na-CMC has exceptional characteristics due to its low price, the ability to form films when fused with semi-crystalline polymers or with crosslinking agent support, super water-solubility, and better biocompatibility, best-swelling capability (in saline solutions and distilled water), equilibrium water uptake, and abundance [5, 6]. However, assigning to its hydrophilicity, less mechanical properties, and low adsorption. These downsides may be conquered by a suitably blended tweaking to refine utility and implant coating application. The choice polymer for blending is sodium alginate (Na-Alg) due to natural casings, high availability, moisture reservation, gel-forming capability, excellent biocompatibility, higher molecular weight, safe, perishable, non-immunogenic, and higher viscosity .
However, the bio-polymeric infrastructure still has drawbacks due to less flexibility of Na-Alg which affected the mechanical properties. Therefore, added surfactants such as Tween(80), To deliver the bio-film to the desired qualities such as flexibility or elasticity (enhance mechanical properties), delay erosion, water adsorption, and gaseous exchange refinement. Tween(80) has a high hydrophilic/lipophilic balance (HLB), which means the hydrophilic fraction with the hydrophilic film matrix may lessen water binding sites quantities while the hydrophobic fraction may perform as a water vapor permeability (WVP) barrier [8, 9]. However; the bio-polymeric infrastructure (Na-CMC/Na-Alg/Tween(80)) still does not include all the specifications of the distinctive bandage for wounds due to antimicrobial activity drawbacks ( no activity) against gram-positive, gram-negative, and fungi. So, this dressing will permit bacterial contamination and imbibe exudates.
Radulescu et al , attained unique properties of various antimicrobial textiles beneficial in different skin dermal infections which contained vital oils. They clarified and compared the effect of oils and emulsions on textiles which concluded the antimicrobial activity of emulsions was weaker than the antimicrobial activity of vital oils before and after impregnation on textiles. Sadeghi et al , studied the polymeric films to sustain the drug release capacity of the ocular inserts by using sodium alginate polymer and enriching the antibacterial activity by using the Linezolid drug. They concluded the alginate copolymer exhibited sustained release ability.
In this study, bio-films comprising sodium carboxymethyl cellulose, sodium alginate, and unification of them with Tween(80) were utilized effectively as wound dressing stimulus. Sodium carboxymethylcellulose, sodium alginate, and Tween(80) were selected due to their favorable properties that were mentioned earlier. Additionally, by blending sodium carboxymethyl cellulose/sodium alginate, the authors aimed to intent the attributes of the bio-polymeric infrastructure. Nevertheless, this was not realized. Forthcoming, Tween(80) was added to enrich the mucoadhesiveness of the bio-film system considering it is willful to be utilized in the dermal bandages. Linezolid antibiotic was padded to ameliorate the antimicrobial aptitude of the refined films. Eventually, this work will intend to attend a unique wound bandage strategy with refined antipathogenic and wound recuperation to avert intense wound infection which can point to outcast effects for instance bacteremia and multitudinous organ dub.