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Validation of the arabic version of the low anterior resection syndrome score
Souadka Amine
national institut of oncology
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1091-9446
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Gastroenterology.
Purpose: Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome. The aim of this study is to translate this tool into arabic and test its psychometric properties in rectal cancer patients, in order to ease its use in clinical practice and future research. Methods: The LARS questionnaire was translated to arabic and administered to a total of 143 patients. A subgroup of 42 patients took the test twice for test-retest reliability. Internal consistency was examined through cronbach’s alpha. The score results were correlated to the EORTC QLQ-C30 questionnaire for convergent validity assessment while discriminant validity was established through the ability of the LARS score to differentiate patients with different clinical and pathological criteria. Results: The arabic version of the LARS score was completed by 143 patients. The internal consistency was demonstrated through a cronbach alpha score of 0.66. The agreement between the test and retest was established by a Bland Altman plot with 95% limits of agreement. 85.6% of patients remained in the same LARS category. The LARS score showed negative correlation with all five of the QLQ-C30 functional scales as well as positive correlation to the diarrhea symptom scale. The questionnaire score differed between patients according to their tumor location, Chemoradiotherapy, type of mesorectal excision and anastomosis. Conclusion: The Arabic version of the LARS score shows good psychometric properties and can be used for bowel dysfunction assessment in clinical and research settings.
Keywords
Rectal cancer, patient outcome assessment, Quality of life, psychometrics, postoperative complications, Low anterior resection syndrome
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CURRENT STATUS: Published
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Editorial decision: Minor revision
On 02 Sep, 2020
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On 27 Aug, 2020
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On 26 Aug, 2020
Editor invited
On 26 Aug, 2020
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Editorial decision: Minor revision
On 25 Aug, 2020
Review #2 received
Received 20 Aug, 2020
Reviewer #3 agreed
On 18 Aug, 2020
Review #3 received
Received 18 Aug, 2020
Reviewer #2 agreed
On 17 Aug, 2020
Reviewer #1 agreed
On 12 Aug, 2020
Review #1 received
Received 12 Aug, 2020
Reviewers invited
Invitations sent on 11 Aug, 2020
Editor assigned
On 10 Aug, 2020
Submission checks complete
On 09 Aug, 2020
Editor invited
On 09 Aug, 2020
Version 1
Posted 27 Feb, 2020
No comments provided
Editorial decision: Major revision
On 28 Jul, 2020
Review #4 received
Received 27 Jul, 2020
Review #2 received
Received 22 Jul, 2020
Review #3 received
Received 14 Jul, 2020
Reviewer #4 agreed
On 29 Jun, 2020
Reviewer #3 agreed
On 27 Jun, 2020
Reviewer #2 agreed
On 26 Jun, 2020
Reviewer #1 agreed
On 15 May, 2020
Review #1 received
Received 15 May, 2020
Reviewers invited
Invitations sent on 19 Mar, 2020
Editor assigned
On 16 Mar, 2020
Submission checks complete
On 26 Feb, 2020
Editor invited
On 25 Feb, 2020
First submitted
On 19 Feb, 2020
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Subject Areas
Gastroenterology & Hepatology
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This preprint is under consideration at BMC Gastroenterology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Validation of the arabic version of the low anterior resection syndrome score
Souadka Amine
national institut of oncology
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1091-9446
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
No comments provided
Editorial decision: Minor revision
On 02 Sep, 2020
Editor assigned
On 27 Aug, 2020
Submission checks complete
On 26 Aug, 2020
Editor invited
On 26 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 25 Aug, 2020
Review #2 received
Received 20 Aug, 2020
Reviewer #3 agreed
On 18 Aug, 2020
Review #3 received
Received 18 Aug, 2020
Reviewer #2 agreed
On 17 Aug, 2020
Reviewer #1 agreed
On 12 Aug, 2020
Review #1 received
Received 12 Aug, 2020
Reviewers invited
Invitations sent on 11 Aug, 2020
Editor assigned
On 10 Aug, 2020
Submission checks complete
On 09 Aug, 2020
Editor invited
On 09 Aug, 2020
Version 1
Posted 27 Feb, 2020
No comments provided
Editorial decision: Major revision
On 28 Jul, 2020
Review #4 received
Received 27 Jul, 2020
Review #2 received
Received 22 Jul, 2020
Review #3 received
Received 14 Jul, 2020
Reviewer #4 agreed
On 29 Jun, 2020
Reviewer #3 agreed
On 27 Jun, 2020
Reviewer #2 agreed
On 26 Jun, 2020
Reviewer #1 agreed
On 15 May, 2020
Review #1 received
Received 15 May, 2020
Reviewers invited
Invitations sent on 19 Mar, 2020
Editor assigned
On 16 Mar, 2020
Submission checks complete
On 26 Feb, 2020
Editor invited
On 25 Feb, 2020
First submitted
On 19 Feb, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Gastroenterology.
Purpose: Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome. The aim of this study is to translate this tool into arabic and test its psychometric properties in rectal cancer patients, in order to ease its use in clinical practice and future research. Methods: The LARS questionnaire was translated to arabic and administered to a total of 143 patients. A subgroup of 42 patients took the test twice for test-retest reliability. Internal consistency was examined through cronbach’s alpha. The score results were correlated to the EORTC QLQ-C30 questionnaire for convergent validity assessment while discriminant validity was established through the ability of the LARS score to differentiate patients with different clinical and pathological criteria. Results: The arabic version of the LARS score was completed by 143 patients. The internal consistency was demonstrated through a cronbach alpha score of 0.66. The agreement between the test and retest was established by a Bland Altman plot with 95% limits of agreement. 85.6% of patients remained in the same LARS category. The LARS score showed negative correlation with all five of the QLQ-C30 functional scales as well as positive correlation to the diarrhea symptom scale. The questionnaire score differed between patients according to their tumor location, Chemoradiotherapy, type of mesorectal excision and anastomosis. Conclusion: The Arabic version of the LARS score shows good psychometric properties and can be used for bowel dysfunction assessment in clinical and research settings.
Figure 1
Figure 2
Figure 3