Anticancer activity
Anti-cancer activity of imine derivatives (3a-m) were evaluated by MTT assay (Table 1-3) using glioblastoma cell line (U87). This cell line was selected as compounds showed promising activity against different causative enzymes of neurodegenerative diseases 24. Among all compound 3g showed potent anti-cancer activity against U87 cell line with IC50 value of 8.83 ± 0.23 µM. Moreover, compounds 3e, 3f, 3h and 3i also showed good to moderate anticancer activities having IC50 values of 17.73 ± 0.05 µM, 21.38 ± 0.02 µM, 12.37 ± 0.09 µM and 19.68 ± 0.06 µM respectively. Compound 3m among thiazole was the most potent compound with IC50 value of 8.86 ± 0.15 µM. Other analogues 3k and 3l also showed good to moderate anticancer activity with IC50 values of 13.68 ± 0.11 µM and 20 ± 0.22 µM respectively. Moreover, oxazole containing compound 3j also showed good activity with IC50 value of 13.17 ± 0.06 µM.
The SAR of semicarbazones and thiosemicarbazone indicated that compound 3g containing meta nitro and para methoxy groups against semicarbazide moiety showed potent inhibitory potential with IC50 value of 8.83 ± 0.23 µM changing methoxy group with hydroxyl in 3f drastically decrease the activity with IC50 value of 21.38 ± 0.02 µM. Changing nitro or methoxy group with halogens in 3e and 3h also decreases the activity with IC50 values of 17.73 ± 0.05 µM and 12.37 ± 0.09 µM correspondingly.
Among thiazoles 3m possessing nitro at meta position against thiazole moiety was most potent thiazole with IC50 value of 8.86 ± 0.15 µM. Changing nitro with halogens in 3k and 3l decreases the activity with IC50 values of 13.68 ± 0.11 µM and 20 ± 0.22 µM respectively. Compound 3j containing oxazole moiety with hydroxy groups at meta and para positions showed good activity with IC50 value of 13.17 ± 0.06 µM.
To evaluate the cytotoxic effect of synthesized derivatives on normal human cells, MTT assay was carried out in contrast to HEK-293 (Normal human embryonic kidney Cell Line). Semicarbazones and thiosemicarbazones were found non-cytotoxic with moderate anti-carcinoma activity except 3g and 3h. Though thiazole derivatives 3k and 3m were found cytotoxic, other derivatives did not show cytotoxicity against HEK-293.
Table 1: Cytotoxicity and anti-cancer assay results of synthesized semicarbazones and thiosemicarbazone
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)
Table 2: Cytotoxicity and anti-cancer assay results of synthesized oxazole and thiazole derivatives
![](data:image/png;base64,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)
Anti-bacterial Activity
Anti-bacterial agents are of ultimate developments in modern medicine responsible to inhibit the growth of bacteria ultimately results in damaging them. Ideally these focus on bacteria devoid of affecting mammalian cells 25. Due to increasing bacterial resistance now a days the development of new anti-bacterial agents is of great significance.
The anti-bacterial potential of semicarbazone, thiosemicarbazone, oxazole and thiazole derivatives (3a-m) was evaluated using Agar well diffusion method against five Gram-positive bacterial strains including Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Corynebacterium diphtheriae, Klebsiella pneumoniae and five Gram-negative bacterial strains including Salmonella Typhi, Eschericia coli, Enterobacter aerogenes, Pseudomonas aeruginosa and Proteus mirabilis. Most of the synthesized derivatives showed almost negligible anti-bacterial activity. Results are illustrated in table 3.
Among semicarbazones only 3c showed slight anti-bacterial action only against gram negative strain i.e., Salmonella Typhi and gram-positive strain Cornybacterium diphthereae with zone of inhibition of 8mm for both the strains at the concentration of 200 µg/ml. Compound 3d having thio-semicarbazide moiety showed mild anti-bacterial potential against two gram positive strains including Staphylococcus aureus, Corynebacterium diphtheriae and a gram negative strain i.e., Proteus mirabilis with zone of inhibition of 10mm, 18mm and 10 mm respectively. Moreover, among oxazole and thiazoles none of the synthesized compound displayed antibacterial activity.
Table 3: Antibacterial activity results
Bacterial Strains
|
Zone of Inhibition (mm) at 200 µg/ml
|
3a
|
3b
|
3c
|
3d
|
3e
|
3f
|
3g
|
3g
|
3h
|
3i
|
3j
|
3k
|
3l
|
3m
|
Salmonella Typhi
|
-
|
-
|
8
|
-
|
-
|
-
|
-
|
-
|
-
|
1
|
-
|
2
|
-
|
-
|
Streptococcus Faecalis
|
-
|
-
|
-
|
2
|
-
|
-
|
-
|
-
|
-
|
4
|
-
|
-
|
2
|
-
|
Staphylococcus aureus
|
-
|
-
|
1
|
10
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
2
|
-
|
Staphylococcus epidermidis
|
-
|
-
|
0
|
4
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Cornybacterium diphthereae
|
-
|
-
|
8
|
18
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Eschericia coli
|
-
|
-
|
2
|
2
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Proteus mirabilis
|
-
|
-
|
2
|
10
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
2
|
-
|
Enterobacter aerogenes
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Pseudomonas aerogenosa
|
-
|
-
|
1
|
1
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
1
|
-
|
Klebsiella pneumonaea
|
-
|
-
|
-
|
2
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|