Pathway ID
|
Pathway
|
P-value
|
Gene Name
|
Number
|
bta04666
|
Fc gamma R-mediated phagocytosis
|
< 0.001
|
PLA2G4Aa, MARCKSL1, VASP, SYK, PIK3R3, FCGR1A, WASF1, CFL1, ASAP1, NCF1, ARPC5, LYN, ARPC2, MAP2K1
|
14
|
bta04668
|
TNF signaling pathway
|
< 0.001
|
CXCL2, SELE, MMP3, PTGS2, CXCL6, VEGFC, SOCS3, MMP14, CASP3, LIF, CSF1, PIK3R3, MAP3K8, TNFAIP3, MAP2K3, MAP2K1
|
16
|
bta04066
|
HIF-1 signaling pathway
|
< 0.001
|
SERPINE1, LDHA, PFKFB3, PGK1, HIF1A, PFKP, TFRC, PIK3R3, MKNK1, ALDOA, ENO1, ENO2, CYBB, MAP2K1
|
14
|
bta04015
|
Rap1 signaling pathway
|
< 0.001
|
ITGAM, THBS1, PDGFRA, ID1, ITGB3, PDGFD, VEGFC, APBB1IP, FYB, PDGFRB, VASP, CSF1, PIK3R3, SIPA1L2, RAP1B, PFN1, MAP2K3, ITGB1, TLN1, PRKD3, MAP2K1
|
21
|
bta04657
|
IL-17 signaling pathway
|
< 0.001
|
CXCL2, CSF3, IL17A, MMP3, S100A9, FOSL1, PTGS2, CXCL6, MMP1, CASP3, TNFAIP3, MAPK6
|
12
|
bta05020
|
Prion diseases
|
0.001
|
NCAM1, LAMC1, FYN, PRKACB, HSPA5, MAP2K1
|
6
|
bta04664
|
Fc epsilon RI signaling pathway
|
0.002
|
ALOX5AP, FCER1A, PLA2G4A, FYN, SYK, PIK3R3, MAP2K3, LYN, MAP2K1
|
9
|
bta04151
|
PI3K-Akt signaling pathway
|
0.002
|
CSF3, THBS2, BDNF, THBS1, ITGA5, IL2RA, PDGFRA, EPOR, ITGB3, PDGFD, VEGFC, COL1A2, LAMA4, ITGA9, LAMC1, GNG2, COL1A1, PDGFRB, CSF1, SYK, PIK3R3, YWHAG, GNB4, COL4A1, ITGB1, CDK2, MAP2K1
|
27
|
bta05134
|
Legionellosis
|
0.002
|
CXCL2, ITGAM, NAIP, CASP3, PYCARD, HSPA8, CD14, SAR1A
|
8
|
bta05146
|
Amoebiasis
|
0.002
|
SERPINB4, CXCL2, ITGAM, COL1A2, CASP3, LAMA4, LAMC1, COL1A1, PRKACB, PIK3R3, CD14, COL4A1
|
12
|
bta04670
|
Leukocyte transendothelial migration
|
0.005
|
ITGAM, MMP2, JAM3, VASP, PIK3R3, MSN, RAP1B, PTPN11, ITGB1, NCF1, CYBB
|
11
|
bta04062
|
Chemokine signaling pathway
|
0.007
|
CXCR2, CXCL2, CCR1, CXCL6, CCL16, PREX1, GNG2, ARRB2, PRKACB, PIK3R3, RAP1B, GNB4, NCF1, LYN, MAP2K1
|
15
|
bta05100
|
Bacterial invasion of epithelial cells
|
0.008
|
ITGA5, CBL, PIK3R3, WASF1, DNM3, ITGB1, ARPC5, ARPC2
|
8
|
bta04145
|
Phagosome
|
0.008
|
THBS2, ITGAM, THBS1, ITGA5, ITGB3, SCARB1, TUBB3, TFRC, FCGR1A, CD14, ITGB1, ATP6V1C1, NCF1, CYBB
|
14
|
bta05165
|
Human papillomavirus infection
|
0.011
|
THBS2, THBS1, PTGS2, WNT2, ITGA5, ITGB3, PKM, COL1A2, CASP3, LAMA4, ITGA9, LAMC1, COL1A1, PDGFRB, PRKACB, NOTCH2, PIK3R3, COL4A1, MX2, ITGB1, ATP6V1C1, CDK2, MAP2K1
|
23
|
bta05167
|
Kaposi sarcoma-associated herpesvirus infection
|
0.023
|
CXCL2, CCR1, PTGS2, E2F3, CASP3, PREX1, GNG2, HIF1A, RCAN1, SYK, PIK3R3, GNB4, MAPKAPK2, LYN, MAP2K1
|
15
|
bta05323
|
Rheumatoid arthritis
|
0.023
|
CXCL2, IL17A, MMP3, CXCL6, MMP1, CD80, CSF1, ATP6V1C1, IL11
|
9
|
bta04392
|
Hippo signaling pathway - multiple species
|
0.026
|
RASSF2, WTIP, TEAD3, WWTR1
|
4
|
bta04014
|
Ras signaling pathway
|
0.030
|
BDNF, PDGFRA, PDGFD, VEGFC, PLA2G4A, GNG2, PDGFRB, PRKACB, CSF1, PIK3R3, RAP1B, GNB4, ABL1, PTPN11, ABL2, MAP2K1
|
16
|
bta04061
|
Viral protein interaction with cytokine and cytokine receptor
|
0.033
|
CXCR2, CXCL2, CCR1, CXCL6, IL2RA, CCL16, IL10RA, CSF1
|
8
|
bta05140
|
Leishmaniasis
|
0.033
|
ITGAM, PTGS2, MARCKSL1, FCGR1A, ITGB1, NCF1, CYBB
|
7
|
bta05145
|
Toxoplasmosis
|
0.035
|
IL10RA, CASP3, LAMA4, LAMC1, LDLR, SOCS1, MAP2K3, HSPA8, ITGB1
|
9
|
bta04060
|
Cytokine-cytokine receptor interaction
|
< 0.001
|
CXCL11b, CX3CR1, CXCL10, CXCL9, NGFR, CXCL14, MSTN, XCL1, IL17RE, BMP3, TNFRSF9, TNFSF10, GHR, CXCR6, CCL5, TNFRSF19, CXCR3, TGFB2
|
18
|
bta04061
|
Viral protein interaction with cytokine and cytokine receptor
|
< 0.001
|
CXCL11, CX3CR1, CXCL10, CXCL9, CXCL14, XCL1, TNFSF10, CCL5, CXCR3
|
9
|
bta04062
|
Chemokine signaling pathway
|
0.001
|
CXCL11, CX3CR1, CXCL10, CXCL9, CXCL14, XCL1, ITK, PRKCZ, CXCR6, CCL5, CXCR3
|
11
|
bta04015
|
Rap1 signaling pathway
|
0.004
|
FGFR4, NGFR, PRKCZ, FGFR2, MET, LPAR2, TLN2, INSR, PDGFA, MAGI3, CTNND1
|
11
|
bta04670
|
Leukocyte trans endothelial migration
|
0.007
|
CLDN1, ITK, OCLN, CLDN3, TXK, EZR, CTNND1
|
7
|
bta05340
|
Primary immunodeficiency
|
0.009
|
CD8A, BLNK, CIITA, TAP1
|
4
|
bta01521
|
EGFR tyrosine kinase inhibitor resistance
|
0.020
|
ERBB3, FGFR2, MET, PDGFA, GAB1
|
5
|
bta04010
|
MAPK signaling pathway
|
0.028
|
FGFR4, ERBB3, NGFR, RPS6KA6, FGFR2, MET, INSR, MAP3K13, PDGFA, MAP3K1, TGFB2
|
11
|
bta04390
|
Hippo signaling pathway
|
0.034
|
RASSF6, PRKCZ, DLG3, PPP2R2B, TCF7, TCF7L2, TGFB2
|
7
|
bta04151
|
PI3K-Akt signaling pathway
|
0.035
|
FGFR4, ERBB3, NGFR, GHR, FGFR2, PPP2R2B, MET, LPAR2, INSR, ITGA6, LAMC2, PDGFA, ITGA3
|
13
|
a The names in bold italic indicated that the genes were up-regulated in S. aureus- inoculated group.
b The names in normal indicated that the genes were down-regulated in S. aureus- inoculated group.
|