Variables used for clustering | (mn/md/p (CI95%)) | (mn/md/p (CI95%)) | (mn/md/p (CI95%)) | | |

Female sex | n: 26, p: 0.57 (0.42 : 0.71) | n: 6, p: 0.33 (0.09 : 0.57) | n: 8, p: 0.31 (0.12 : 0.5) | 0,06 | Chi-square |

Age in months | md: 33.63 (14.97 : 55.17) | md: 3.25 (0.2 : 8.77) | md: 137.13 (102.17 : 169.43) | **< 0,001** | Kruskal-Wallis |

Weight z-score for age | md: -1.3 (-2.18 : -0.51) | md: -0.93 (-2.07 : 0.16) | md: 0.03 (-0.82 : 2.05) | **0,02** | Kruskal-Wallis |

Hearth rate z-score for age (min) | md: -0.32 (-0.62 : 0.35) | md: -2.59 (-5.97 : -0.56) | md: -0.27 (-1.26 : 0.21) | **0,01** | Kruskal-Wallis |

Hearth rate z-score for age (mean) | mn: 1.82 (1.4 : 2.24) | mn: 0.77 (-0.11 : 1.64) | mn: 1.99 (1.41 : 2.58) | 0,93 | ANOVA |

Hearth rate z-score for age (max) | md: 3.82 (3.44 : 4.31) | md: 2.7 (1.85 : 4.55) | md: 5.13 (4.39 : 5.38) | **0,002** | Kruskal-Wallis |

Respiratory rate z-score for age (min) | md: -2.33 (-2.78 : -1.99) | md: -3.61 (-5.14 : -2.89) | md: -1.06 (-2.33 : -0.63) | **< 0,001** | Kruskal-Wallis |

Respiratory rate z-score for age (mean) | mn: 1.07 (0.2 : 1.95) | mn: -1.04 (-2.6 : 0.51) | mn: 2.18 (0.87 : 3.49) | 0,32 | ANOVA |

Respiratory rate z-score for age (max) | mn: 6 (3.49 : 8.51) | mn: 2.63 (-0.38 : 5.63) | mn: 7.49 (5.01 : 9.98) | 0,59 | ANOVA |

Diastolic arterial pressure z-score for age (min) | md: -0.15 (-0.22 : -0.09) | md: -0.09 (0.39) | md: 0.05 (-0.1 : 0.1) | **0,01** | Kruskal-Wallis |

Diastolic arterial pressure z-score for age (mean) | mn: 0.24 (0.19 : 0.29) | mn: 0.44 (0.09 : 0.78) | mn: 0.54 (0.48 : 0.61) | **< 0,001** | ANOVA |

Diastolic arterial pressure z-score for age (max) | mn: 0.78 (0.7 : 0.87) | mn: 1.23 (0.31 : 2.15) | mn: 1.15 (1.02 : 1.28) | **< 0,001** | ANOVA |

Median arterial pressure z-score for age (min) | md: -0.18 (-0.29 : -0.13) | md: -0.72 (-0.3) | md: 0.04 (-0.11 : 0.09) | **< 0,001** | Kruskal-Wallis |

Median arterial pressure z-score for age (mean) | mn: 0.15 (0.11 : 0.18) | mn: 0.15 (-0.02 : 0.32) | mn: 0.41 (0.35 : 0.47) | **< 0,001** | ANOVA |

Median arterial pressure z-score for age (max) | mn: 0.54 (0.47 : 0.62) | mn: 0.78 (0.06 : 1.5) | mn: 0.85 (0.76 : 0.94) | **< 0,001** | ANOVA |

Systolic arterial pressure z-score for age (min) | mn: -0.21 (-0.28 : -0.14) | mn: -0.35 (-0.58 : -0.12) | mn: -0.01 (-0.07 : 0.06) | **< 0,001** | ANOVA |

Systolic arterial pressure z-score for age (mean) | mn: 0.1 (0.05 : 0.14) | mn: -0.07 (-0.16 : 0.02) | mn: 0.32 (0.27 : 0.36) | **< 0,001** | ANOVA |

Systolic arterial pressure z-score for age (max) | md: 0.37 (0.28 : 0.43) | md: 0.32 (0.69) | md: 0.61 (0.56 : 0.69) | **< 0,001** | Kruskal-Wallis |

Daily diuresis in mL/kg/day | mn: 1.85 (1.16 : 2.54) | mn: 3.4 (0 : 7.27) | mn: 1.51 (0.68 : 2.33) | 0,90 | ANOVA |

Temperature in ºC (min) | mn: 36.74 (36.46 : 37.02) | mn: 34.82 (34.19 : 35.46) | mn: 36.7 (36.22 : 37.17) | 0,50 | ANOVA |

Temperature in ºC (mean) | mn: 37.02 (36.75 : 37.28) | mn: 35.57 (35.15 : 35.98) | mn: 37.15 (36.72 : 37.58) | 0,97 | ANOVA |

Temperature in ºC (max) | mn: 37.31 (36.96 : 37.67) | mn: 36.18 (35.65 : 36.7) | mn: 37.7 (37.18 : 38.21) | 0,43 | ANOVA |

Oxygen saturation in % (min) | md: 94 (93 : 95) | md: 79 (61 : 87) | md: 95.5 (94 : 96) | **0,002** | Kruskal-Wallis |

Oxygen saturation in % (mean) | md: 97.88 (96.94 : 98.48) | md: 94 (91.33 : 96.56) | md: 98.27 (97.38 : 98.86) | **0,02** | Kruskal-Wallis |

Venous oxygen saturation in % (min) | mn: 56.12 (50.16 : 62.08) | mn: 34.53 (24.92 : 44.14) | mn: 62.96 (57.16 : 68.76) | 0,30 | ANOVA |

Venous oxygen saturation in % (max) | mn: 77.24 (71.62 : 82.85) | mn: 71.73 (59.86 : 83.61) | mn: 78.6 (74.59 : 82.61) | 0,81 | ANOVA |

Carboxyhemoglobin in % (max) | mn: 2.3 (1.89 : 2.71) | mn: 2.49 (2.03 : 2.94) | mn: 2.55 (2.1 : 3) | 0,38 | ANOVA |

Inspirited oxygen fraction in % (max) | mn: 57.78 (46.9 : 68.65) | mn: 88.33 (76.73 : 99.93) | mn: 46.53 (31.11 : 61.96) | 0,81 | ANOVA |

Inspirited oxygen fraction in % (mean) | md: 36.19 (27.5 : 48) | md: 55.59 (40 : 69.76) | md: 26 (22.6 : 40) | **< 0,001** | Kruskal-Wallis |

Capillary glucose in mg/dL (min) | mn: 100.11 (90.91 : 109.31) | mn: 75.53 (53.84 : 97.22) | mn: 111.77 (96.74 : 126.81) | 0,39 | ANOVA |

Capillary glucose in mg/dL (max) | md: 156.5 (121 : 193) | md: 156.5 (121 : 193) | md: 156.5 (121 : 193) | **0,01** | Kruskal-Wallis |

Calcium ion in mg/dL (min) | md: 4.6 (4.2 : 4.7) | md: 3.6 (2.9 : 3.8) | md: 4.54 (4.4 : 4.7) | **< 0,001** | Kruskal-Wallis |

Creatinine in mg/dL (max) | mn: 3.18 (0 : 7.05) | mn: 3.92 (0 : 10.08) | mn: 3.98 (0 : 7.98) | 0,77 | ANOVA |

Phosphate in mg/dL (max) | md: 4.8 (4.2 : 5.2) | md: 8 (5.8 : 10.7) | md: 4.25 (3.8 : 4.9) | **< 0,001** | Kruskal-Wallis |

Reactive C protein in mg/L (max) | md: 55.9 (30.56 : 98.8) | md: 11.4 (7.37 : 35.49) | md: 163.6 (80.73 : 199.21) | **< 0,001** | Kruskal-Wallis |

Lymphocytes · 1000/µL (min) | md: 1.4 (0.86 : 2.3) | md: 0.9 (0.5 : 2.29) | md: 0.21 (0.02 : 0.56) | **< 0,001** | Kruskal-Wallis |

Lymphocytes · 1000/µL (max) | md: 3.24 (1.9 : 7) | md: 4.42 (1.2 : 21) | md: 0.24 (0.1 : 0.9) | **< 0,001** | Kruskal-Wallis |

Neutrophils · 1000/µL (min) | md: 7.25 (5.57 : 11.66) | md: 2.65 (1.9 : 3.77) | md: 1.43 (0.03 : 5.54) | **< 0,001** | Kruskal-Wallis |

Neutrophils · 1000/µL (max) | mn: 13.65 (9.61 : 17.69) | mn: 5.53 (3.83 : 7.23) | mn: 6.01 (2.77 : 9.25) | **0,002** | ANOVA |

Mechanical ventilation | n: 36, p: 0.78 (0.66 : 0.91) | n: 18, mn: 1 | n: 15, p: 0.58 (0.37 : 0.78) | **0,005** | Chi-square |

Hemodiafiltration | n: 1, p: 0.02 (0 : 0.07) | n: 5, p: 0.28 (0.05 : 0.51) | n: 1, p: 0.04 (0 : 0.12) | **0,002** | Chi-square |

ECMO | n: 1, p: 0.02 (0 : 0.07) | n: 15, p: 0.83 (0.64 : 1.02) | n: 0, p: 0 | **< 0,001** | Chi-square |

Thermic blanket | n: 5, p: 0.11 (0.02 : 0.2) | n: 1, p: 0.06 (0 : 0.17) | n: 0, p: 0 | 0,20 | Chi-square |

Non-clustering variables | (mn/md/p (CI95%)) | (mn/md/p (CI95%)) | (mn/md/p (CI95%)) | | |

EtCO2 in Torr (min) | md: 30 (27 : 37) | md: 9 (8 : 10) | md: 31 (0 : 38) | **< 0,001** | Kruskal-Wallis |

EtCO2 in Torr (mean) | mn: 42.56 (35.27 : 49.86) | mn: 22.33 (16.54 : 28.12) | mn: 35.19 (25.63 : 44.74) | **0,02** | ANOVA |

EtCO2 in Torr (max) | mn: 51.35 (43.8 : 58.9) | mn: 33.08 (22.85 : 43.32) | mn: 43.25 (32.67 : 53.83) | **0,04** | ANOVA |

End expiratory pressure (mean) | md: 5.5 (5 : 6.57) | md: 6.97 (5 : 7.67) | md: 5.14 (0 : 5.17) | 0,13 | Kruskal-Wallis |

End expiratory pressure (max) | md: 6 (5 : 7) | md: 9 (5 : 10) | md: 6 (0 : 9) | 0,10 | Kruskal-Wallis |

Cerebral NIRS in % (min) | mn: 49.67 (39.43 : 59.9) | mn: 47.25 (35.27 : 59.23) | mn: 61.25 (45.11 : 77.39) | 0,44 | ANOVA |

Cerebral NIRS in % (mean) | mn: 59.59 (47.6 : 71.59) | mn: 66.11 (59.64 : 72.58) | mn: 70.73 (64.26 : 77.2) | 0,12 | ANOVA |

Troponin in ng/L (max) | md: 249 (0 : 1653) | md: 2732 (329 : 4853) | md: 29 (0 : 35) | **0,01** | Kruskal-Wallis |

Cardiogenic shock | n: 9, p: 0.2 (0.08 : 0.31) | n: 13, p: 0.72 (0.49 : 0.95) | n: 2, p: 0.08 (0 : 0.19) | **< 0,001** | Chi-square |

Inflammatory shock | n: 24, p: 0.52 (0.37 : 0.67) | n: 3, p: 0.17 (0 : 0.36) | n: 21, p: 0.81 (0.65 : 0.97) | **< 0,001** | Chi-square |

*Septic shock* | n: 23, p: 0.5 (0.35 : 0.65) | n: 3, p: 0.17 (0 : 0.36) | n: 20, p: 0.77 (0.6 : 0.94) | **< 0,001** | Chi-square |

*Anaphylactic shock* | n: 2, p: 0.04 (0 : 0.1) | n: 0, p: 0 | n: 0, p: 0 | 0,38 | Chi-square |

Hypovolemic shock | n: 7, p: 0.15 (0.04 : 0.26) | n: 5, p: 0.28 (0.05 : 0.51) | n: 3, p: 0.12 (0 : 0.25) | 0,34 | Chi-square |

*Hypovolemic secondary to traumatism* | n: 3, p: 0.07 (0 : 0.14) | n: 0, mn: 0 | n: 1, p: 0.04 (0 : 0.12) | 0,52 | Chi-square |

*Hypovolemic secondary to surgery* | n: 1, p: 0.02 (0 : 0.07) | n: 1, p: 0.06 (0 : 0.17) | n: 1, p: 0.04 (0 : 0.12) | 0,78 | Chi-square |

Non-specified shock | n: 9, p: 0.2 (0.08 : 0.31) | n: 0, p: 0 | n: 1, p: 0.04 (0 : 0.12) | **0,03** | Chi-square |

Cardiac surgery | n: 3, p: 0.2 (0.08 : 0.31) | n: 8, p: 0.72 (0.49 : 0.95) | n: 2, p: 0.08 (0 : 0.19) | **< 0,001** | Kruskal-Wallis |

Oncologic patients | n: 2, p: 0.04 (0 : 0.1) | n: 1, p: 0.06 (0 : 0.17) | n: 8, p: 0.31 (0.12 : 0.5) | **0,003** | Kruskal-Wallis |

Length of stay in days | md: 6 (3 : 9) | md: 11 (4 : 29) | md: 4 (2 : 7) | **0,02** | Kruskal-Wallis |

Exitus | n: 3, p: 0.07 (0 : 0.14) | n: 6, p: 0.33 (0.09 : 0.57) | n: 1, p: 0.04 (0 : 0.12) | **0,004** | Chi-square |