Cost-effectiveness analysis of fruquintinib for metastatic colorectal cancer third-line treatment in China
Background: In this study, we analyze the cost-effectiveness of fruquintinib as third-line treatment for patients with metastatic colorectal cancer in China, especially after a recent price drop suggested by the National Healthcare Security Administration.
Methods: A Markov model was developed to investigate the cost-effectiveness of fruquintinib compared to placebo among patients with metastatic colorectal cancer. Effectiveness was measured in quality-adjusted life years (QALY). The Chinese healthcare payer’s perspective was considered with a lifetime horizon, including direct medical cost (2019 US dollars [USD]). A willing‐to‐pay threshold was set at USD 27,130/QALY, which is three times the gross domestic product (GDP) per capita. We examined the robustness of the model in one-way and probabilistic sensitivity analysis.
Results: Fruquintinib was associated with better health outcomes than placebo (0.640 vs 0.478 QALYs) with a higher cost (USD 20750.9 vs USD 12042.2), resulting in an incremental cost-effectiveness ratio (ICER) of USD 53508.7 per QALY. This ICER is 25% lower than the one calculated before the price drop (USD 70952.6 per QALY).
Conclusion: After the price negotiation, the drug becomes cheaper and the ICER is lower, but the drug is still not cost effective under the standard of 3 times GDP willing‐to‐pay threshold. For patients with metastatic colorectal cancer in China, fruquintinib is not a cost-effective option under the current circumstances in China.
Figure 1
Figure 2
Figure 3
Posted 10 Oct, 2020
On 14 Jul, 2020
On 12 Jul, 2020
Received 12 Jul, 2020
Invitations sent on 11 Jul, 2020
On 09 Jul, 2020
On 08 Jul, 2020
On 08 Jul, 2020
On 01 Jul, 2020
Received 17 Jun, 2020
On 15 Jun, 2020
Received 19 Apr, 2020
On 17 Apr, 2020
Invitations sent on 20 Mar, 2020
On 26 Feb, 2020
On 25 Feb, 2020
On 25 Feb, 2020
On 25 Feb, 2020
Cost-effectiveness analysis of fruquintinib for metastatic colorectal cancer third-line treatment in China
Posted 10 Oct, 2020
On 14 Jul, 2020
On 12 Jul, 2020
Received 12 Jul, 2020
Invitations sent on 11 Jul, 2020
On 09 Jul, 2020
On 08 Jul, 2020
On 08 Jul, 2020
On 01 Jul, 2020
Received 17 Jun, 2020
On 15 Jun, 2020
Received 19 Apr, 2020
On 17 Apr, 2020
Invitations sent on 20 Mar, 2020
On 26 Feb, 2020
On 25 Feb, 2020
On 25 Feb, 2020
On 25 Feb, 2020
Background: In this study, we analyze the cost-effectiveness of fruquintinib as third-line treatment for patients with metastatic colorectal cancer in China, especially after a recent price drop suggested by the National Healthcare Security Administration.
Methods: A Markov model was developed to investigate the cost-effectiveness of fruquintinib compared to placebo among patients with metastatic colorectal cancer. Effectiveness was measured in quality-adjusted life years (QALY). The Chinese healthcare payer’s perspective was considered with a lifetime horizon, including direct medical cost (2019 US dollars [USD]). A willing‐to‐pay threshold was set at USD 27,130/QALY, which is three times the gross domestic product (GDP) per capita. We examined the robustness of the model in one-way and probabilistic sensitivity analysis.
Results: Fruquintinib was associated with better health outcomes than placebo (0.640 vs 0.478 QALYs) with a higher cost (USD 20750.9 vs USD 12042.2), resulting in an incremental cost-effectiveness ratio (ICER) of USD 53508.7 per QALY. This ICER is 25% lower than the one calculated before the price drop (USD 70952.6 per QALY).
Conclusion: After the price negotiation, the drug becomes cheaper and the ICER is lower, but the drug is still not cost effective under the standard of 3 times GDP willing‐to‐pay threshold. For patients with metastatic colorectal cancer in China, fruquintinib is not a cost-effective option under the current circumstances in China.
Figure 1
Figure 2
Figure 3