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Research article
Jing Cang
Corresponding Author
ORCiD: https://orcid.org/0000-0003-3093-0076
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Background: The ideal fraction of nitrous oxide (N2O) in oxygen (O2) for rapid lung collapse remains unclear. Accordingly, this prospective trial aimed to determine the 50% effective concentration (EC50) and 95% effective concentration (EC95) of N2O in O2 for rapid lung collapse.
Methods: This study included 38 consecutive patients undergoing video-assisted thoracoscopic surgery (VATS). The lung collapse score (LCS) of each patient during one-lung ventilation was evaluated by the same surgeon. The first patient received 30% N2O in O2, and the subsequent N2O fraction in O2 was determined by the LCS of the previous patient using the Dixon up-and-down method. The testing interval was set at 10%, and the lowest concentration was 10% (10%, 20%, 30%, 40%, or 50%). The EC50 and EC95 of N2O in O2 for rapid lung collapse were analyzed using a probit test.
Results: According to the up-and-down method, the N2O fraction in O2 at which all patients exhibited successful lung collapse was 50%. The EC50 and EC95 of N2O in O2 for rapid lung collapse were 27.7% (95% confidence interval 19.9%–35.7%) and 48.7% (95% confidence interval 39.0%–96.3%), respectively.
Conclusions: In patients undergoing VATS, the EC50 and EC95 of N2O in O2 for rapid lung collapse were 27.7% and 48.7%, respectively.
Trial registration: http://www.chictr.org/cn/ Identifier ChiCTR19 00021474, registered on 22 February 2019
Keywords
Nitrous Oxide, Lung collapse, One-Lung Ventilation, double lumen
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CURRENT STATUS: Published
View the published article at BMC Anesthesiology.
Version 4
Posted 22 Jul, 2020
No community comments so far
Submission checks complete
On 16 Jul, 2020
Editorial decision: Accept
On 16 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 14 Jul, 2020
Review #1 received
Received 13 Jul, 2020
Reviewer #2 agreed
On 04 Jul, 2020
Review #2 received
Received 04 Jul, 2020
Reviewers invited
Invitations sent on 01 Jul, 2020
Reviewer #1 agreed
On 01 Jul, 2020
Editor assigned
On 30 Jun, 2020
Submission checks complete
On 29 Jun, 2020
Editor invited
On 29 Jun, 2020
No comments provided
Review #4 received
Received 25 Jun, 2020
Editorial decision: Major revision
On 25 Jun, 2020
Review #3 received
Received 22 Jun, 2020
Reviewer #4 agreed
On 11 Jun, 2020
Reviewer #3 agreed
On 10 Jun, 2020
Review #2 received
Received 25 May, 2020
Review #1 received
Received 25 May, 2020
Reviewers invited
Invitations sent on 13 May, 2020
Reviewer #1 agreed
On 13 May, 2020
Reviewer #2 agreed
On 13 May, 2020
Editor assigned
On 07 May, 2020
Editor invited
On 06 May, 2020
Submission checks complete
On 29 Feb, 2020
No comments provided
Review #1 received
Received 01 May, 2020
Editorial decision: Major revision
On 01 May, 2020
Review #2 received
Received 03 Apr, 2020
Reviewer #3 agreed
On 31 Mar, 2020
Reviewers invited
Invitations sent on 05 Mar, 2020
Reviewer #1 agreed
On 05 Mar, 2020
Reviewer #2 agreed
On 05 Mar, 2020
Editor assigned
On 27 Feb, 2020
First submitted
On 26 Feb, 2020
Submission checks complete
On 26 Feb, 2020
Editor invited
On 26 Feb, 2020
Metrics
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Subject Areas
Anesthesiology & Pain Medicine
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A new preprint design is coming!
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See the published version of this preprint at BMC Anesthesiology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Jing Cang
Corresponding Author
ORCiD: https://orcid.org/0000-0003-3093-0076
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Anesthesiology.
Version 4
Posted 22 Jul, 2020
No community comments so far
Submission checks complete
On 16 Jul, 2020
Editorial decision: Accept
On 16 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 14 Jul, 2020
Review #1 received
Received 13 Jul, 2020
Reviewer #2 agreed
On 04 Jul, 2020
Review #2 received
Received 04 Jul, 2020
Reviewers invited
Invitations sent on 01 Jul, 2020
Reviewer #1 agreed
On 01 Jul, 2020
Editor assigned
On 30 Jun, 2020
Submission checks complete
On 29 Jun, 2020
Editor invited
On 29 Jun, 2020
No comments provided
Review #4 received
Received 25 Jun, 2020
Editorial decision: Major revision
On 25 Jun, 2020
Review #3 received
Received 22 Jun, 2020
Reviewer #4 agreed
On 11 Jun, 2020
Reviewer #3 agreed
On 10 Jun, 2020
Review #2 received
Received 25 May, 2020
Review #1 received
Received 25 May, 2020
Reviewers invited
Invitations sent on 13 May, 2020
Reviewer #1 agreed
On 13 May, 2020
Reviewer #2 agreed
On 13 May, 2020
Editor assigned
On 07 May, 2020
Editor invited
On 06 May, 2020
Submission checks complete
On 29 Feb, 2020
No comments provided
Review #1 received
Received 01 May, 2020
Editorial decision: Major revision
On 01 May, 2020
Review #2 received
Received 03 Apr, 2020
Reviewer #3 agreed
On 31 Mar, 2020
Reviewers invited
Invitations sent on 05 Mar, 2020
Reviewer #1 agreed
On 05 Mar, 2020
Reviewer #2 agreed
On 05 Mar, 2020
Editor assigned
On 27 Feb, 2020
First submitted
On 26 Feb, 2020
Submission checks complete
On 26 Feb, 2020
Editor invited
On 26 Feb, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Anesthesiology & Pain Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Anesthesiology.
Background: The ideal fraction of nitrous oxide (N2O) in oxygen (O2) for rapid lung collapse remains unclear. Accordingly, this prospective trial aimed to determine the 50% effective concentration (EC50) and 95% effective concentration (EC95) of N2O in O2 for rapid lung collapse.
Methods: This study included 38 consecutive patients undergoing video-assisted thoracoscopic surgery (VATS). The lung collapse score (LCS) of each patient during one-lung ventilation was evaluated by the same surgeon. The first patient received 30% N2O in O2, and the subsequent N2O fraction in O2 was determined by the LCS of the previous patient using the Dixon up-and-down method. The testing interval was set at 10%, and the lowest concentration was 10% (10%, 20%, 30%, 40%, or 50%). The EC50 and EC95 of N2O in O2 for rapid lung collapse were analyzed using a probit test.
Results: According to the up-and-down method, the N2O fraction in O2 at which all patients exhibited successful lung collapse was 50%. The EC50 and EC95 of N2O in O2 for rapid lung collapse were 27.7% (95% confidence interval 19.9%–35.7%) and 48.7% (95% confidence interval 39.0%–96.3%), respectively.
Conclusions: In patients undergoing VATS, the EC50 and EC95 of N2O in O2 for rapid lung collapse were 27.7% and 48.7%, respectively.
Trial registration: http://www.chictr.org/cn/ Identifier ChiCTR19 00021474, registered on 22 February 2019
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
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