Machine learning, especially deep learning, has been increasingly becoming a potentially powerful tool in the diagnosis and management of diseases. In this study, we utilized logistic regression (LR), decision tree (DT), gradient boosted decision tree (GBDT), support vector machine (SVM), and deep multilayer perceptron (MLP) as machine learning models to rapidly diagnose the mycoplasma pneumoniae pneumonia (MPP) in children patients. The classification task was carried out after applying the preprocessing procedure to the MPP dataset. The most efficient results are obtained by GBDT. It provides the best performance with an accuracy of 93.7%. In contrast to standard raw feature weighting, the feature importance takes the underlying correlation structure of the features into account. The most crucial feature of GBDT is the “pulmonary infiltrates range” with a score of 0.5925, followed by “cough” (0.0953) and “pleural effusion” (0.0492). We publicly share our full implementation with the dataset and trained models at https://github.com/zhenguonie/2021_AI4MPP.