Background:
VTE of in hospital cancer patients is increasing. However, the incidence of VTE, the diagnostic value of Khorana model and the correlation of driving-gene status with VTE remains unknown.
Methods:
Data of cancer patients was collected. Ultrasonography and radiography were used to detect VTE. VTE incidence was calculated for overall patients, different cancer types, mutant genes, and Khorana model subgroups. The diagnostic value of Khorana model was also evaluated. The correlation of driving gene with VTE was analysed.
Results:
3831 patients were enrolled. The overall VTE rate was 4.7%. In different organs: gynaecology (11.9%) > gastric (5.71%) > others (5.33%) > lung (4.74%) > colorectum (4.51%) > breast (3.77%) > oesophagus (2.4%). In mutant genes: C-Met (6.72%) > EGFR (5.24%) > ALK (4.26%) > Her-2 (4.04%) > KRAS (3.7%) > ROS1 (3.03%) > PD-L1 (1.33%) > PD-1 (0%). The mutation-positive vs mutation-negative VTE incidence for the Khorana model subgroups were 2.03% vs 3.33% (low-risk group, p = 0.773), 4.43% vs 6.52% (middle-risk group, p = 0.237) and 9.84% vs 13.79% (high-risk group, p = 0.842). Meanwhile, the sensitivities of overall, mutation-positive, and negative groups were: 13.33%, 10.00% and 20.00%. The specificities were 92.02%, 92.55% and 90.67%. Areas under the ROC cure were 0.706, 0.719 and 0.681 (P = 0.007, 0.020 and 0.177). The Spearman correlation coefficient for the correlation of mutation status with VTE was − 0.024 (P = 0.690).
Conclusions:
Chinese in-hospital cancer patients VTE incidence was approximately in accordance with international data. Khorana model had a moderate diagnostic value. No correlation of gene mutation with VTE was observed.