Background: SARS-COV-2 is a new virus responsible for the outbreak of respiratory illness known as Corona Virus Disease 2019 (COVID-19). Mycoplasma is an uncommon co-infected pathogen with SARS-COV-2 and has not been reported yet. Besides, Computed Tomography (CT), used as an accessory examination, may play a more significant role this time.
Case presentation: A 49-year-old female presented with cough, expectoration and chest congestion followed by elevated CRP and ESR. CT images showed ground-glass opacities in bilateral lower lobes and patchy and striate shadow in right upper lobe. IgM antibody of Mycoplasma pneumoniae was positive and RT-PCR outcome of sputum was positive for the SARS-COV-2 nucleic acid. Her diagnosis of COVID-19 was made on the basis of laboratory results, chest CT images, clinical manifestations and epidemiologic characteristics. She was treated with combination therapy for 17 days following which she showed marked recovery.
Conclusion: Co-infection of SARS-COV-2 and Mycoplasma in COVID-19 patients appears to be uncommon. Computed tomography is an acceptive way to make primary diagnosis and treatment for patients as soon as possible. Combination therapy of antiviral, anti-inflammatory, traditional Chinese medical herbal and supportive care may be a reference for further progress.