This preprint is under consideration at Cancers of the Head & Neck. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research
Improvement of a Delayed Swallowing Reflex Following Treatment for Advanced Head and Neck Cancer
Akira Ohkoshi
Tohoku Daigaku
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0652-7041
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The latency of the swallowing reflex is an important factor causing dysphagia in head and neck cancer patients. Although there are many reports comparing voluntary swallowing function before and after treatment, few studies have focused on the latency of the swallowing reflex, which is a risk factor for pneumonia due to silent aspiration. The aim of this retrospective study was to clarify the changes in the latency of the swallowing reflex before and after treatment.
Methods: The latency of the swallowing reflex was quantified using the time from the injection of 1 ml of distilled water into the pharynx through a nasal catheter to the onset of swallowing.
Results: The latency time of the swallowing reflex was significantly decreased 3 months after treatment compared to before treatment. A significant reduction was also observed in patients with pharyngeal cancer who underwent chemoradiation therapy.
Conclusions: This retrospective study showed that a delayed swallowing reflex improved with treatment in advanced head and neck cancer patients.
Keywords
Head and neck cancer, swallowing disorder, latency time of the swallowing reflex
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CURRENT STATUS: Under Review
Version 3
Posted 17 May, 2020
No community comments so far
Editor assigned
On 03 May, 2020
Submission checks complete
On 02 May, 2020
Editor invited
On 02 May, 2020
No comments provided
Review #2 received
Received 27 Apr, 2020
Editorial decision: Minor revision
On 27 Apr, 2020
Review #1 received
Received 21 Apr, 2020
Reviewer #2 agreed
On 17 Apr, 2020
Reviewer #1 agreed
On 15 Apr, 2020
Reviewers invited
Invitations sent on 15 Apr, 2020
Editor assigned
On 14 Apr, 2020
Submission checks complete
On 13 Apr, 2020
Editor invited
On 13 Apr, 2020
No comments provided
Review #1 received
Received 24 Mar, 2020
Editorial decision: Major revision
On 24 Mar, 2020
Review #2 received
Received 19 Mar, 2020
Reviewer #2 agreed
On 11 Mar, 2020
Reviewer #1 agreed
On 09 Mar, 2020
Reviewers invited
Invitations sent on 04 Mar, 2020
Editor assigned
On 04 Mar, 2020
Submission checks complete
On 03 Mar, 2020
Editor invited
On 03 Mar, 2020
First submitted
On 28 Feb, 2020
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This preprint is under consideration at Cancers of the Head & Neck. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Improvement of a Delayed Swallowing Reflex Following Treatment for Advanced Head and Neck Cancer
Akira Ohkoshi
Tohoku Daigaku
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0652-7041
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 3
Posted 17 May, 2020
No community comments so far
Editor assigned
On 03 May, 2020
Submission checks complete
On 02 May, 2020
Editor invited
On 02 May, 2020
No comments provided
Review #2 received
Received 27 Apr, 2020
Editorial decision: Minor revision
On 27 Apr, 2020
Review #1 received
Received 21 Apr, 2020
Reviewer #2 agreed
On 17 Apr, 2020
Reviewer #1 agreed
On 15 Apr, 2020
Reviewers invited
Invitations sent on 15 Apr, 2020
Editor assigned
On 14 Apr, 2020
Submission checks complete
On 13 Apr, 2020
Editor invited
On 13 Apr, 2020
No comments provided
Review #1 received
Received 24 Mar, 2020
Editorial decision: Major revision
On 24 Mar, 2020
Review #2 received
Received 19 Mar, 2020
Reviewer #2 agreed
On 11 Mar, 2020
Reviewer #1 agreed
On 09 Mar, 2020
Reviewers invited
Invitations sent on 04 Mar, 2020
Editor assigned
On 04 Mar, 2020
Submission checks complete
On 03 Mar, 2020
Editor invited
On 03 Mar, 2020
First submitted
On 28 Feb, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The latency of the swallowing reflex is an important factor causing dysphagia in head and neck cancer patients. Although there are many reports comparing voluntary swallowing function before and after treatment, few studies have focused on the latency of the swallowing reflex, which is a risk factor for pneumonia due to silent aspiration. The aim of this retrospective study was to clarify the changes in the latency of the swallowing reflex before and after treatment.
Methods: The latency of the swallowing reflex was quantified using the time from the injection of 1 ml of distilled water into the pharynx through a nasal catheter to the onset of swallowing.
Results: The latency time of the swallowing reflex was significantly decreased 3 months after treatment compared to before treatment. A significant reduction was also observed in patients with pharyngeal cancer who underwent chemoradiation therapy.
Conclusions: This retrospective study showed that a delayed swallowing reflex improved with treatment in advanced head and neck cancer patients.
Figure 1
Figure 2
Figure 3