In this paper, we have tried to examine the effect of loans granted by the international monetary fund on the human development index (measured by 3 components). To do this, we used a sample of 12 countries in the MENA region. Our sample is composed of two groups of countries namely; A group of 6 countries from the North Africa region (Algeria, Djibouti, Egypt, Mauritania Morocco and Tunisia) and a group of 6 countries from the Middle East region (Iran, Jordan, Kuwait, Lebanon, Syria, and Yemen) during the period (1990-2019). The econometric approach used in this study is based on the analysis of panel data. Our main results have shown that the flows granted by the (IMF) which have been used in the financing of living sectors have a positive influence on the human development index. Similarly, trade openness and foreign direct investment are positively and significantly correlated with the HDI. The variables, gross fixed capital formation, and domestic private sector credits negatively affect the human development index of MENA countries.