Gamma irradiation was applied for the elimination of different pollutants in groundwater. Two techniques of irradiation have been studied. The first technique, irradiation-reduction, resulted in un-soluble metals forming aggregations, such as cadmium, mercury, and lead, which can be separated out of the solution. Different parameters, such as different hydroxyl scavengers and different gasses, were used for water de-aeration. Metal ion removal yields were 99.4%, 97.8%, and 96.9%, for Cd2+, Hg2+, and Pb2+ respectively at the best-studied conditions. The second technique was irradiation coupled with ozonization which performed organics degradation. The procedure can reduce the values of turbidity, chemical oxygen demand (COD), biological oxygen demand (BOD), total organic carbon (TOC), and total dissolved solids (TDS). The bacterial colony counts, and rotavirus, have diminished. A constant value of COD/BOD ratios at different purification steps was about 1.2. For the sake of conferment, this methodology of degradation of a simulated organic detergent and antibacterial such as triclosan has been studied. Degradation of triclosan, using reduction techniques, produced fragments dangerous to human health which were ensured by high values of COD and TOC. These fragments were completely degraded using the two techniques (reduction followed by oxidation) which were conducted to attain the least COD and TOC values. The two techniques of irradiation proved to be successful method for people highly sensitive to pollutants in water consumed.