Rapid urbanisation, characterised by population increase and spatial development, is pushing the frontiers of major African cities from old urban cores outward into peri-urban areas. A key outcome is the transitioning of land uses and variations to customary land rights. Yet, understandings of the transformational processes and driving forces in peri-urbanisation remains underexplored. This article, using a case study of a peri-urban area of Kumasi, Ghana’s second largest city, contributes to the body of literature on peri-urbanisation by: (i) analysing the spatio-temporal evolution of a peri urban area; and (ii) examining key underpinning processes and patterns of peri-urban spatial change. Qualitative research methods involving interviews with traditional and local statutory authorities, and peri-urban developers, as well as map analysis, Landsat images, and photographs were used. Findings show rapid but unregulated spatial changes in peri-urban Kumasi, driven by increasing demand for land, land speculation, commodification, and infrastructure projects. Peri-urbanisation processes and patterns were shaped by multiple factors such as modernisation, urban restructuring, and individual home ownership aspirations. The process of spatial change assumed a linear and drastic permanent transition, producing less credence to intermediate and temporary land uses.