Deep soft soil of the Yangtze River floodplain in Nanjing has a special interlayer structure, which provides favorable conditions for the application of vacuum tube-well dewatering technology. This paper focuses on the design, construction and treatment effect of vacuum tube-well dewatering technology. The hydrological parameters and the hydraulic connections between the various layers of the site have been ascertained through two simple single-well multi-holes pumping tests. Moreover, the layout of vacuum tube-wells and depressurization wells in a test site with 84m length and 84m width was designed based on the above parameters. Field tests of vacuum tube-well dewatering technology were conducted on the test site. And the changes of groundwater level, ground settlement and pore water pressure during the test was monitored. The CPTU test technology was used to quickly evaluate the engineering properties of the site before and after treatment. Finally, combined with the settlement monitoring data, the hyperbolic method was used to predict the final settlement. The results indicated that consolidation efficiency of vacuum tube-well dewatering technology has obvious advantages. Implications of this study can provide a reference for the construction design of the site's ground improvement consolidation and other similar projects.