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Research Article
Pooya Vatankhah
Shiraz University of Medical Sciences
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Intravenous bolus injection of fentanyl has been frequently reported to be associated with cough reflex during patient anesthesia. However, the search for the most effective protocol continues. This study aimed to compare the effect of reducing cough reflex after injection of fentanyl in a fusion protocol by combining the injections of lidocaine and Huffing maneuver and comparing with a placebo control group, before anesthesia induction.
Methods
This prospective randomized controlled trial study was performed on 400 patients who were divided into four groups of combined protocol (group 1), lidocaine group (group 2), Huffing maneuver group (group 3), and the control receiving normal saline (group 4). Then patients were injected with 2. 5 µg /kg fentanyl and monitored for two minutes regarding their cough reflex, as well as the severity.
Results
In group 1, 9 patients (9%), in group 2, 22 patients (22%), in the group3 45 patients (45%) and in the group 4, 75 patients (75%), developed cough reflex following fentanyl injection. Also, 13 patients (13%) developed moderate and 4 (4%) developed severe coughs in the control group reported, while no reports of severe or moderate cough were among the intervention groups. There was a significant difference between the intervention group and the control group both in terms of the rate and severity of the fentanyl-induced cough.
Conclusion
By using a combination of lidocaine injection along and Huffing maneuver, better results can be obtained in reducing the frequency, and also the severity of cough followed by fentanyl injection.
Trial registration:
Trial Registration: The trial was registered with IRCT.IR (09/03/2018-No. IRCT20141009019470N74).
Keywords
fentanyl, lidocaine, Huffing maneuver, cough, combination protocol
No competing interests reported.
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CURRENT STATUS: Published
View the published article at BMC Anesthesiology.
Version 1
Posted 08 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 22 Feb, 2021
Reviews received
Received 02 Feb, 2021
Reviewers agreed
On 01 Feb, 2021
Reviewers invited
Invitations sent on 01 Feb, 2021
Editor assigned
On 01 Feb, 2021
Editor invited
On 01 Feb, 2021
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On 01 Feb, 2021
First submitted
On 28 Jan, 2021
Metrics
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Subject Areas
Anesthesiology & Pain Medicine
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Anesthesiology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Pooya Vatankhah
Shiraz University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Anesthesiology.
Version 1
Posted 08 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 22 Feb, 2021
Reviews received
Received 02 Feb, 2021
Reviewers agreed
On 01 Feb, 2021
Reviewers invited
Invitations sent on 01 Feb, 2021
Editor assigned
On 01 Feb, 2021
Editor invited
On 01 Feb, 2021
Submission checks complete
On 01 Feb, 2021
First submitted
On 28 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Anesthesiology & Pain Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Anesthesiology.
Background
Intravenous bolus injection of fentanyl has been frequently reported to be associated with cough reflex during patient anesthesia. However, the search for the most effective protocol continues. This study aimed to compare the effect of reducing cough reflex after injection of fentanyl in a fusion protocol by combining the injections of lidocaine and Huffing maneuver and comparing with a placebo control group, before anesthesia induction.
Methods
This prospective randomized controlled trial study was performed on 400 patients who were divided into four groups of combined protocol (group 1), lidocaine group (group 2), Huffing maneuver group (group 3), and the control receiving normal saline (group 4). Then patients were injected with 2. 5 µg /kg fentanyl and monitored for two minutes regarding their cough reflex, as well as the severity.
Results
In group 1, 9 patients (9%), in group 2, 22 patients (22%), in the group3 45 patients (45%) and in the group 4, 75 patients (75%), developed cough reflex following fentanyl injection. Also, 13 patients (13%) developed moderate and 4 (4%) developed severe coughs in the control group reported, while no reports of severe or moderate cough were among the intervention groups. There was a significant difference between the intervention group and the control group both in terms of the rate and severity of the fentanyl-induced cough.
Conclusion
By using a combination of lidocaine injection along and Huffing maneuver, better results can be obtained in reducing the frequency, and also the severity of cough followed by fentanyl injection.
Trial registration:
Trial Registration: The trial was registered with IRCT.IR (09/03/2018-No. IRCT20141009019470N74).
No competing interests reported.
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