[1] E.J. Benjamin, P. Muntner, A. Alonso, M.S. Bittencourt, C.W. Callaway, A.P. Carson, A.M. Chamberlain, A.R. Chang, S. Cheng, S.R. Das, F.N. Delling, L. Djousse, M.S.V. Elkind, J.F. Ferguson, M. Fornage, L.C. Jordan, S.S. Khan, B.M. Kissela, K.L. Knutson, T.W. Kwan, D.T. Lackland, T.T. Lewis, J.H. Lichtman, C.T. Longenecker, M.S. Loop, P.L. Lutsey, S.S. Martin, K. Matsushita, A.E. Moran, M.E. Mussolino, M. O'Flaherty, A. Pandey, A.M. Perak, W.D. Rosamond, G.A. Roth, U.K.A. Sampson, G.M. Satou, E.B. Schroeder, S.H. Shah, N.L. Spartano, A. Stokes, D.L. Tirschwell, C.W. Tsao, M.P. Turakhia, L.B. VanWagner, J.T. Wilkins, S.S. Wong, S.S. Virani, A.H.A.C. Epid, P.S. Comm, S.S. Subcomm, Heart Disease and Stroke Statistics-2019 Update A Report From the American Heart Association, Circulation, 139 (2019) E56-E528.
[2] M. Cohen, C. Boiangiu, M. Abidi, Therapy for ST-Segment Elevation Myocardial Infarction Patients Who Present Late or Are Ineligible for Reperfusion Therapy, J Am Coll Cardiol, 55 (2010) 1895-1906.
[3] L.D. Dias, K.R. Casali, C. Ghem, M.K. da Silva, G. Sausen, P.B. Palma, D.T. Covas, R.A.K. Kalil, B.D. Schaan, N.B. Nardi, M.M. Markoski, Mesenchymal stem cells from sternum: the type of heart disease, ischemic or valvular, does not influence the cell culture establishment and growth kinetics, J Transl Med, 15 (2017) 161.
[4] K.R. Vrijsen, J.A. Maring, S.A. Chamuleau, V. Verhage, E.A. Mol, J.C. Deddens, C.H. Metz, K. Lodder, E.C. van Eeuwijk, S.M. van Dommelen, P.A. Doevendans, A.M. Smits, M.J. Goumans, J.P. Sluijter, Exosomes from Cardiomyocyte Progenitor Cells and Mesenchymal Stem Cells Stimulate Angiogenesis Via EMMPRIN, Adv Healthc Mater, 5 (2016) 2555-2565.
[5] A.R. Williams, J.M. Hare, Mesenchymal Stem Cells Biology, Pathophysiology, Translational Findings, and Therapeutic Implications for Cardiac Disease, Circ Res, 109 (2011) 923-940.
[6] A.E. Shafei, M.A. Ali, H.G. Ghanem, A.I. Shehata, A.A. Abdelgawad, H.R. Handal, K.A. Talaat, A.E. Ashaal, A.S. El-Shal, Mesenchymal stem cell therapy: A promising cell-based therapy for treatment of myocardial infarction, J Gene Med, 19 (2017).
[7] Z.W. Zhang, J.J. Yang, W.Y. Yan, Y.X. Li, Z.Y. Shen, T. Asahara, Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair, J Am Heart Assoc, 5 (2016).
[8] E. Suzuki, D. Fujita, M. Takahashi, S. Oba, H. Nishimatsu, Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease, World J Stem Cells, 8 (2016) 297-305.
[9] M. Khan, E. Nickoloff, T. Abramova, J. Johnson, S.K. Verma, P. Krishnamurthy, A.R. Mackie, E. Vaughan, V.N. Garikipati, C. Benedict, V. Ramirez, E. Lambers, A. Ito, E. Gao, S. Misener, T. Luongo, J. Elrod, G. Qin, S.R. Houser, W.J. Koch, R. Kishore, Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction, Circ Res, 117 (2015) 52-64.
[10] T. Pan, P. Jia, N. Chen, Y. Fang, Y. Liang, M. Guo, X. Ding, Delayed Remote Ischemic Preconditioning ConfersRenoprotection against Septic Acute Kidney Injury via Exosomal miR-21, Theranostics, 9 (2019) 405-423.
[11] F. Arslan, R.C. Lai, M.B. Smeets, L. Akeroyd, A. Choo, E.N.E. Aguor, L. Timmers, H.V. van Rijen, P.A. Doevendans, G. Pasterkamp, S.K. Lim, D.P. de Kleijn, Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury, Stem Cell Res, 10 (2013) 301-312.
[12] S.G. Ong, W.H. Lee, M. Huang, D. Dey, K. Kodo, V. Sanchez-Freire, J.D. Gold, J.C. Wu, Cross Talk of Combined Gene and Cell Therapy in Ischemic Heart Disease Role of Exosomal MicroRNA Transfer, Circulation, 130 (2014) S60-+.
[13] Y. Kuwabara, K. Ono, T. Horie, H. Nishi, K. Nagao, M. Kinoshita, S. Watanabe, O. Baba, Y. Kojima, S. Shizuta, M. Imai, T. Tamura, T. Kita, T. Kimura, Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage, Circ-Cardiovasc Gene, 4 (2011) 446-U287.
[14] X.T. Ma, J.J. Wang, J. Li, C.L. Ma, S.Z. Chen, W. Lei, Y. Yang, S.M. Liu, J. Bihl, C. Chen, Loading MiR-210 in Endothelial Progenitor Cells Derived Exosomes Boosts Their Beneficial Effects on Hypoxia/Reoxygeneation-Injured Human Endothelial Cells via Protecting Mitochondrial Function, Cell Physiol Biochem, 46 (2018) 664-675.
[15] G. Zaccagnini, B. Maimone, P. Fuschi, D. Maselli, G. Spinetti, C. Gaetano, F. Martelli, Overexpression of miR-210 and its significance in ischemic tissue damage, Sci Rep-Uk, 7 (2017).
[16] S.M. Eken, H. Jin, E. Chernogubova, Y.H. Li, N. Simon, C.Y. Sun, G. Korzunowicz, A. Busch, A. Backlund, C. Osterholm, A. Razuvaev, T. Renne, H.H. Eckstein, J. Pelisek, P. Eriksson, M.G. Diez, L.P. Matic, I.N. Schellinger, U. Raaz, N.J. Leeper, G.K. Hansson, G. Paulsson-Berne, U. Hedin, L. Maegdefessel, MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions, Circ Res, 120 (2017) 633-+.
[17] K. Essandoh, L. Yang, X. Wang, W. Huang, D. Qin, J. Hao, Y. Wang, B. Zingarelli, T. Peng, G.C. Fan, Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction, Biochim Biophys Acta, 1852 (2015) 2362-2371.
[18] R.K. Mutharasan, V. Nagpal, Y. Ichikawa, H. Ardehali, microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects, Am J Physiol Heart Circ Physiol, 301 (2011) H1519-1530.
[19] R.K. Mutharasan, V. Nagpal, Y. Ichikawa, H. Ardehali, microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects, Am J Physiol-Heart C, 301 (2011) H1519-H1530.
[20] E. Braunwald, Cell-Based Therapy in Cardiac Regeneration: An Overview, Circ Res, 123 (2018) 132-137.
[21] K.M. Broughton, M.A. Sussman, Enhancement Strategies for Cardiac Regenerative Cell Therapy: Focus on Adult Stem Cells, Circ Res, 123 (2018) 177-187.
[22] M.N. Banerjee, R. Bolli, J.M. Hare, Clinical Studies of Cell Therapy in Cardiovascular Medicine: Recent Developments and Future Directions, Circ Res, 123 (2018) 266-287.
[23] X.L. Tang, Q.H. Li, G. Rokosh, S.K. Sanganalmath, N. Chen, Q.H. Ou, H. Stowers, G. Hunt, R. Bolli, Long-Term Outcome of Administration of c-kit(POS) Cardiac Progenitor Cells After Acute Myocardial Infarction Transplanted Cells Do not Become Cardiomyocytes, but Structural and Functional Improvement and Proliferation of Endogenous Cells Persist for at Least One Year, Circ Res, 118 (2016) 1091-1105.
[24] W. Ying, M. Riopel, G. Bandyopadhyay, Y. Dong, A. Birmingham, J.B. Seo, J.M. Ofrecio, J. Wollam, A. Hernandez-Carretero, W.X. Fu, P.P. Li, J.M. Olefsky, Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity, Cell, 171 (2017) 372-+.
[25] W. Yan, X. Wu, W. Zhou, M.Y. Fong, M. Cao, J. Liu, X. Liu, C.H. Chen, O. Fadare, D.P. Pizzo, J. Wu, L. Liu, X. Liu, A.R. Chin, X. Ren, Y. Chen, J.W. Locasale, S.E. Wang, Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells, Nat Cell Biol, 20 (2018) 597-609.
[26] L. Gao, L. Wang, T. Dai, K. Jin, Z. Zhang, S. Wang, F. Xie, P. Fang, B. Yang, H. Huang, H. van Dam, F. Zhou, L. Zhang, Tumor-derived exosomes antagonize innate antiviral immunity, Nat Immunol, 19 (2018) 233-245.
[27] H. Wang, H. Flach, M. Onizawa, L. Wei, M.T. McManus, A. Weiss, Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210, Nat Immunol, 15 (2014) 393-401.
[28] S.M. Eken, H. Jin, E. Chernogubova, Y. Li, N. Simon, C. Sun, G. Korzunowicz, A. Busch, A. Backlund, C. Osterholm, A. Razuvaev, T. Renne, H.H. Eckstein, J. Pelisek, P. Eriksson, M. Gonzalez Diez, L. Perisic Matic, I.N. Schellinger, U. Raaz, N.J. Leeper, G.K. Hansson, G. Paulsson-Berne, U. Hedin, L. Maegdefessel, MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions, Circ Res, 120 (2017) 633-644.
[29] X. Ma, J. Wang, J. Li, C. Ma, S. Chen, W. Lei, Y. Yang, S. Liu, J. Bihl, C. Chen, Loading MiR-210 in Endothelial Progenitor Cells Derived Exosomes Boosts Their Beneficial Effects on Hypoxia/Reoxygeneation-Injured Human Endothelial Cells via Protecting Mitochondrial Function, Cell Physiol Biochem, 46 (2018) 664-675.
[30] Z.Y. Meng, H.L. Kang, W. Duan, J. Zheng, Q.N. Li, Z.J. Zhou, MicroRNA-210 Promotes Accumulation of Neural Precursor Cells Around Ischemic Foci After Cerebral Ischemia by Regulating the SOCS1-STAT3-VEGF-C Pathway, J Am Heart Assoc, 7 (2018).
[31] X. Ke, R. Yan, Z. Sun, Y. Cheng, A. Meltzer, N. Lu, X. Shu, Z. Wang, B. Huang, X. Liu, Z. Wang, J.H. Song, C.K. Ng, S. Ibrahim, J.M. Abraham, E.J. Shin, S. He, S.J. Meltzer, Esophageal Adenocarcinoma-Derived Extracellular Vesicle MicroRNAs Induce a Neoplastic Phenotype in Gastric Organoids, Neoplasia, 19 (2017) 941-949.
[32] C. Li, X. Zhou, Y. Wang, S. Jing, C. Yang, G. Sun, Q. Liu, Y. Cheng, L. Wang, miR210 regulates esophageal cancer cell proliferation by inducing G2/M phase cell cycle arrest through targeting PLK1, Mol Med Rep, 10 (2014) 2099-2104.
[33] Y. Lu, J. Huang, S. Geng, H. Chen, C. Song, S. Zhu, S. Zhao, M. Yuan, X. Li, H. Hu, MitoKATP regulating HIF/miR210/ISCU signaling axis and formation of a positive feedback loop in chronic hypoxia-induced PAH rat model, Exp Ther Med, 13 (2017) 1697-1701.
[34] C. Li, M. Zhao, C. Zhang, W. Zhang, X. Zhao, X. Duan, W. Xu, miR210 modulates respiratory burst in Apostichopus japonicus coelomocytes via targeting Toll-like receptor, Dev Comp Immunol, 65 (2016) 377-381.
[35] J.X. Lv, J. Zhou, R.Q. Tong, B. Wang, X.L. Chen, Y.Y. Zhuang, F. Xia, X.D. Wei, Hypoxiainduced miR210 contributes to apoptosis of mouse spermatocyte GC2 cells by targeting Kruppellike factor 7, Mol Med Rep, 19 (2019) 271-279.
[36] C. Xiao, K. Wang, Y. Xu, H. Hu, N. Zhang, Y. Wang, Z. Zhong, J. Zhao, Q. Li, D. Zhu, C. Ke, S. Zhong, X. Wu, H. Yu, W. Zhu, J. Chen, J. Zhang, J. Wang, X. Hu, Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of miR-125b, Circ Res, 123 (2018) 564-578.
[37] P. Paul, A. Chakraborty, D. Sarkar, M. Langthasa, M. Rahman, R.K.S. Singha, A.K. Malakar, S. Chakraborty, Interplay between miRNAs and human diseases, J Cell Physiol, 233 (2018) 2007-2018.
[38] K.W. Witwer, B.W.M. Van Balkom, S. Bruno, A. Choo, M. Dominici, M. Gimona, A.F. Hill, D. De Kleijn, M. Koh, R.C. Lai, S.A. Mitsialis, L.A. Ortiz, E. Rohde, T. Asada, W.S. Toh, D.J. Weiss, L. Zheng, B. Giebel, S.K. Lim, Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications, J Extracell Vesicles, 8 (2019) 1609206.