Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of individuals worldwide. Understanding of the risk factors for Alzheimer's is in its preliminary stages, but researchers have recently made several advancements in searching for treatments for this damaging disorder. This paper aims to garner greater insight into two potential risk factors: APOE ε4 allele and Traumatic Brain injuries (TBIs), specifically their leverage on disease diagnosis through metrics measuring hallmarks of the disease: beta-amyloid plaques and neurofibrillary tangles. Data from the Allen Brain Institute was analyzed through statistical tests that included chi-squared, bar charts, stacked bar charts, two-way ANOVAs, and t-tests to deduce these risk factors' mechanisms in impacting Alzheimer's. From the analyses, it could be understood that the APOE ε4 allele is a significant genetic predisposition for this disease, although a causal relationship could not be determined. On the other hand, TBIs were found to play an additive role in the development of Alzheimer's, which was less significant than the APOE ε4 allele's role since there was a higher correlation between TBIs and non-Alzheimer's dementia, specifically neurofibrillary tangle predominant dementia (NFTPD). Analysis of risk factors provides a means for optimizing therapy by identifying and allocating resources more efficiently to those most vulnerable, as well as improved drug delivery through treatments that target biological pathways which initiate specific biomarkers formation.