[1] N. Patrick, E. Emanski, M.A. Knaub, Acute and chronic low back pain, The Medical clinics of North America 98(4) (2014) 777-89, xii.
[2] D. Hoy, P. Brooks, F. Blyth, R. Buchbinder, The Epidemiology of low back pain, Best practice & research. Clinical rheumatology 24(6) (2010) 769-81.
[3] S.P. Hughes, A.J. Freemont, D.W. Hukins, A.H. McGregor, S. Roberts, The pathogenesis of degeneration of the intervertebral disc and emerging therapies in the management of back pain, The Journal of bone and joint surgery. British volume 94(10) (2012) 1298-304.
[4] M.A. Adams, P.J. Roughley, What is intervertebral disc degeneration, and what causes it?, Spine 31(18) (2006) 2151-61.
[5] P. Colombier, J. Clouet, O. Hamel, L. Lescaudron, J. Guicheux, The lumbar intervertebral disc: from embryonic development to degeneration, Joint, bone, spine : revue du rhumatisme 81(2) (2014) 125-9.
[6] A.J. Freemont, The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain, Rheumatology (Oxford, England) 48(1) (2009) 5-10.
[7] M. Stefanakis, M. Al-Abbasi, I. Harding, P. Pollintine, P. Dolan, J. Tarlton, M.A. Adams, Annulus fissures are mechanically and chemically conducive to the ingrowth of nerves and blood vessels, Spine 37(22) (2012) 1883-91.
[8] Y. Aoki, A. Nakajima, S. Ohtori, H. Takahashi, F. Watanabe, M. Sonobe, F. Terajima, M. Saito, K. Takahashi, T. Toyone, A. Watanabe, T. Nakajima, M. Takazawa, K. Nakagawa, Increase of nerve growth factor levels in the human herniated intervertebral disc: can annular rupture trigger discogenic back pain?, Arthritis research & therapy 16(4) (2014) R159.
[9] A.J. Freemont, T.E. Peacock, P. Goupille, J.A. Hoyland, J. O'Brien, M.I. Jayson, Nerve ingrowth into diseased intervertebral disc in chronic back pain, Lancet (London, England) 350(9072) (1997) 178-81.
[10] S. Ohtori, G. Inoue, M. Miyagi, K. Takahashi, Pathomechanisms of discogenic low back pain in humans and animal models, The spine journal ,15(6) (2015) 1347-55.
[11] W.R.M. FRCA, Intervertebral disc as a source of pain, Continuing Education in Anaesthesia, Critical Care & Pain Advance (2012).
[12] A.L. Binch, A.A. Cole, L.M. Breakwell, A.L. Michael, N. Chiverton, L.B. Creemers, A.K. Cross, C.L. Le Maitre, Nerves are more abundant than blood vessels in the degenerate human intervertebral disc, Arthritis research & therapy 17 (2015) 370.
[13] W.E. Johnson, B. Caterson, S.M. Eisenstein, S. Roberts, Human intervertebral disc aggrecan inhibits endothelial cell adhesion and cell migration in vitro, Spine 30(10) (2005) 1139-47.
[14] W.E. Johnson, B. Caterson, S.M. Eisenstein, D.L. Hynds, D.M. Snow, S. Roberts, Human intervertebral disc aggrecan inhibits nerve growth in vitro, Arthritis and rheumatism 46(10) (2002) 2658-64.
[15] D. Purmessur, M.C. Cornejo, S.K. Cho, P.J. Roughley, R.J. Linhardt, A.C. Hecht, J.C. Iatridis, Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability, The spine journal , 15(5) (2015) 1060-9.
[16] J. Melrose, S. Roberts, S. Smith, J. Menage, P. Ghosh, Increased nerve and blood vessel ingrowth associated with proteoglycan depletion in an ovine anular lesion model of experimental disc degeneration, Spine 27(12) (2002) 1278-85.
[17] L. Xin, C. Zhang, F. Zhong, S. Fan, W. Wang, Z. Wang, Minimal invasive annulotomy for induction of disc degeneration and implantation of poly (lactic-co-glycolic acid) (PLGA) plugs for annular repair in a rabbit model, European journal of medical research 21(1) (2016) 7.
[18] L. Xin, W. Xu, L. Yu, S. Fan, W. Wang, F. Yu, Z. Wang, Effects of annulus defects and implantation of poly(lactic-co-glycolic acid) (PLGA)/fibrin gel scaffolds on nerves ingrowth in a rabbit model of annular injury disc degeneration, Journal of orthopaedic surgery and research 12(1) (2017) 73.
[19] S.E. Gullbrand, N.R. Malhotra, T.P. Schaer, Z. Zawacki, J.T. Martin, J.R. Bendigo, A.H. Milby, G.R. Dodge, E.J. Vresilovic, D.M. Elliott, R.L. Mauck, L.J. Smith, A large animal model that recapitulates the spectrum of human intervertebral disc degeneration, Osteoarthritis and cartilage 25(1) (2017) 146-156.
[20] Y. Shen, A.P. Tenney, S.A. Busch, K.P. Horn, F.X. Cuascut, K. Liu, Z. He, J. Silver, J.G. Flanagan, PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration, Science (New York, N.Y.) 326(5952) (2009) 592-6.
[21] S.C. Jefferson, N.J. Tester, D.R. Howland, Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection, The Journal of neuroscience, 31(15) (2011) 5710-20.
[22] K. Zukor, Z. He, Regenerative medicine: drawing breath after spinal injury, Nature 475(7355) (2011) 177-8.
[23] J.C. Lee, H.J. Min, S. Lee, S.C. Seong, M.C. Lee, Effect of chondroitinase ABC on adhesion and behavior of synovial membrane-derived mesenchymal stem cells in rabbit partial-thickness chondral defects, Journal of orthopaedic research,31(8) (2013) 1293-301.
[24] E. Muir, F. De Winter, J. Verhaagen, J. Fawcett, Recent advances in the therapeutic uses of chondroitinase ABC, Experimental neurology 321 (2019) 113032.
[25] W. Wang, B. Li, J. Yang, L. Xin, Y. Li, H. Yin, Y. Qi, Y. Jiang, H. Ouyang, C. Gao, The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs, Biomaterials 31(34) (2010) 8964-73.
[26] X.K. Li, S.X. Cai, B. Liu, Z.L. Xu, X.Z. Dai, K.W. Ma, S.Q. Lin, L. Yang, K.L. Sung, X.B. Fu, Characteristics of PLGA-gelatin complex as potential artificial nerve scaffold, Colloids and surfaces. B, Biointerfaces 57(2) (2007) 198-203.
[27] Y. Xiong, Y.S. Zeng, C.G. Zeng, B.L. Du, L.M. He, D.P. Quan, W. Zhang, J.M. Wang, J.L. Wu, Y. Li, J. Li, Synaptic transmission of neural stem cells seeded in 3-dimensional PLGA scaffolds, Biomaterials 30(22) (2009) 3711-22.
[28] D.Y. Lee, B.H. Choi, J.H. Park, S.J. Zhu, B.Y. Kim, J.Y. Huh, S.H. Lee, J.H. Jung, S.H. Kim, Nerve regeneration with the use of a poly(l-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 34(1) (2006) 50-6.
[29] J. Han, P. Lazarovici, C. Pomerantz, X. Chen, Y. Wei, P.I. Lelkes, Co-electrospun blends of PLGA, gelatin, and elastin as potential nonthrombogenic scaffolds for vascular tissue engineering, Biomacromolecules 12(2) (2011) 399-408.
[30] Z. Pan, J. Ding, Poly(lactide-co-glycolide) porous scaffolds for tissue engineering and regenerative medicine, Interface focus 2(3) (2012) 366-77.
[31] G.Y. Zhou Q, Gao C. , Microstructure and mechanical properties of poly(l-lactide) scaffolds fabricated by gelatin particle leaching method, J Appl Polym Sci 98(3) (2005) 1373–9.
[32] A. Dresdale, E.A. Rose, V. Jeevanandam, K. Reemtsma, F.O. Bowman, J.R. Malm, Preparation of fibrin glue from single-donor fresh-frozen plasma, Surgery 97(6) (1985) 750-5.
[33] R.J. Hoogendoorn, P.I. Wuisman, T.H. Smit, V.E. Everts, M.N. Helder, Experimental intervertebral disc degeneration induced by chondroitinase ABC in the goat, Spine 32(17) (2007) 1816-25.
[34] A.J. Hyatt, D. Wang, J.C. Kwok, J.W. Fawcett, K.R. Martin, Controlled release of chondroitinase ABC from fibrin gel reduces the level of inhibitory glycosaminoglycan chains in lesioned spinal cord, Journal of controlled release,147(1) (2010) 24-9.
[35] K. Masuda, Y. Aota, C. Muehleman, Y. Imai, M. Okuma, E.J. Thonar, G.B. Andersson, H.S. An, A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration, Spine 30(1) (2005) 5-14.
[36] K. Masuda, Y. Imai, M. Okuma, C. Muehleman, K. Nakagawa, K. Akeda, E. Thonar, G. Andersson, H.S. An, Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model, Spine 31(7) (2006) 742-54.
[37] C.W. Pfirrmann, A. Metzdorf, M. Zanetti, J. Hodler, N. Boos, Magnetic resonance classification of lumbar intervertebral disc degeneration, Spine 26(17) (2001) 1873-8.
[38] R.W. Farndale, D.J. Buttle, A.J. Barrett, Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue, Biochimica et biophysica acta 883(2) (1986) 173-7.
[39] L. Lao, H. Tan, Y. Wang, C. Gao, Chitosan modified poly(L-lactide) microspheres as cell microcarriers for cartilage tissue engineering, Colloids and surfaces. B, Biointerfaces 66(2) (2008) 218-25.
[40] Y. Aoki, K. Akeda, H. An, C. Muehleman, K. Takahashi, H. Moriya, K. Masuda, Nerve fiber ingrowth into scar tissue formed following nucleus pulposus extrusion in the rabbit anular-puncture disc degeneration model: effects of depth of puncture, Spine 31(21) (2006) E774-80.
[41] L. Xin, G.C. Han, F.D. Zhao, X. Zhao, G. Li, S.W. Fan, [In vivo study of innervation of degenerative intervertebral discs in rabbit anular-injury model], Journal of Zhejiang University. Medical sciences 38(5) (2009) 485-92.
[42] W.E. Johnson, S. Sivan, K.T. Wright, S.M. Eisenstein, A. Maroudas, S. Roberts, Human intervertebral disc cells promote nerve growth over substrata of human intervertebral disc aggrecan, Spine 31(11) (2006) 1187-93.
[43] H.I. Katsuhiko Ishibashi, Chemonucleolysis With Chondroitin Sulfate ABC Endolyase as a Novel Minimally Invasive Treatment for Patients With Lumbar Intervertebral Disc Herniation, J Spine Surg 5 (2019) S115-S121.
[44] J.P. Norcross, G.E. Lester, P. Weinhold, L.E. Dahners, An in vivo model of degenerative disc disease, Journal of orthopaedic research , 21(1) (2003) 183-8.
[45] Y. Imai, M. Okuma, H.S. An, K. Nakagawa, M. Yamada, C. Muehleman, E. Thonar, K. Masuda, Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC, Spine 32(11) (2007) 1197-205.
[46] L.J. Varden, D.T. Nguyen, A.J. Michalek, Slow depressurization following intradiscal injection leads to injectate leakage in a large animal model, JOR spine 2(3) (2019) e1061.
[47] P.C. Marion Fusellier, Longitudinal Comparison of Enzyme- And Laser-Treated Intervertebral Disc by MRI, X-Ray, and Histological Analyses Reveals Discrepancies in the Progression of Disc Degeneration: A Rabbit Study, BioMed research international (2016) 1-12.
[48] G.D. O'Connell, R.J. Nims, J. Green, A.D. Cigan, G.A. Ateshian, C.T. Hung, Time and dose-dependent effects of chondroitinase ABC on growth of engineered cartilage, Eur Cell Mater 27 (2014) 312-320.
[49] J.-C. Lee, H.J. Min, S. Lee, S.C. Seong, M.C. Lee, Effect of chondroitinase ABC on adhesion and behavior of synovial membrane-derived mesenchymal stem cells in rabbit partial-thickness chondral defects, Journal of orthopaedic research,31(8) (2013) 1293-1301.