Ethics approval and consent to participate
The study protocol was established, according to the ethical guidelines of the Helsinki Declaration and was approved by the local ethic committee of our hospital (KMUHIRB-E(II)-20190280). Each patient gave written informed consent.
Consent for publication
Availability of data and materials
All data generated or analyzed during this study are included in this published article.
The authors declare that they have no conflicts of interests.
This work was supported by grants through funding from the Ministry of Science and Technology (MOST108-2321-B-037-001, MOST107-2321-B-037-003, MOST107-2314-B-037-116, MOST107-2314-B-037-022-MY2, MOST107-2314-B-037-023-MY2) and the Ministry of Health and Welfare (MOHW107-TDU-B-212-123006, MOHW107-TDU-B-212-114026B, MOHW108-TDU-B-212-133006, MOHW108-TDU-B-212-124026) funded by Health and welfare surcharge of tobacco products, and the Kaohsiung Medical University Hospital (KMTTH-108-042, KMUH108-8R34, KMUH108-8R35, KMUH108-8M33, KMUH108-8M35, KMUH108-8M36, KMUHS10801, KMUHSA10804, KMUHS10807, KMUH-DK109005~3) and Center for Cancer Research, Kaohsiung Medical University (KMU-TC108A04). In addition, this study was supported by the Grant of Taiwan Precision Medicine Initiative, Academia Sinica, Taiwan, R.O.C
Conceptualization, Hon-Yi Shi; Data curation, Hsiang-Lin Tsai; Formal analysis, Hon-Yi Shi; Investigation, Wei-Chiao Chang; Resources, Ming-Yii Huang, Ching-Wen Huang, Wei-Chih Su and Jaw-Yuan Wang; Supervision, Jaw-Yuan Wang; Writing – original draft, Chun-Ming Huang.
1Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
2Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
3Department of Radiation Oncology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
4Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
5Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan
6Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
7Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
8Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
9School of Pharmacy, Taipei Medical University, Taipei, Taiwan
10Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Taiwan
11Department of Business Management, National Sun Yat-sen University, Taiwan
12Deoartment of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
13Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan