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Research article
Relationships between menstrual status and obesity phenotypes in women: a cross-sectional study in northern China
Dong Li
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Endocrine Disorders.
Background: One of most important concerns of postmenopausal women is obesity. The relationships between menstruation status and obesity phenotypes are unclear. This study aimed to assess the associations between menstrual status and different obesity phenotypes in women.
Methods: In total, 5373 women aged ≥40 years were recruited from the Jidong and Kailuan communities. Basic information was collected via clinical examination, laboratory testing and standardized questionnaires. The women were stratified into the following three groups: menstrual period, menopausal transition period and postmenopausal period. General obesity was defined as a body mass index (BMI) of ≥28 kg/m2. Central obesity was defined as a waist-to-hip ratio (WHR) of >0.85. Visceral obesity was defined as the presence of nonalcoholic fatty liver disease (NAFLD) and increased pericardial fat volume (PFV).
Results: The numbers of women in the menstrual, menopausal transition, and postmenopausal periods were 2807 (52.2%), 675 (12.6%) and 1891 (35.2%), respectively. The adjusted odds ratio (OR) and 95% confidence interval (CI) for central obesity among women in the menopausal transition and postmenopausal periods compared with women in the menstrual period were 1.34 (0.87-2.05) and 0.87 (0.57-1.33), respectively. The OR for NAFLD among postmenopausal women was 1.78 (1.44-2.20). The adjusted β-coefficient (standard error, SE) for PFV among postmenopausal women was 41.25 (7.49). The adjusted OR for general obesity among postmenopausal women was 1.01 (0.77-1.34).
Conclusions: This study demonstrated that menopause is an independent risk factor for central and visceral obesity but not general obesity.
Keywords
menstruation, obesity, phenotypes, postmenopausal
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CURRENT STATUS: Published
Version 2
Posted 28 May, 2020
Published
On 22 Jun, 2020
Published
On 22 Jun, 2020
No community comments so far
Review #1 received
Received 27 May, 2020
Reviewer #1 agreed
On 22 May, 2020
Reviewer #2 agreed
On 22 May, 2020
Reviewers invited
Invitations sent on 21 May, 2020
Editor assigned
On 19 May, 2020
Submission checks complete
On 18 May, 2020
Editor invited
On 18 May, 2020
No comments provided
Review #1 received
Received 27 Apr, 2020
Editorial decision: Major revision
On 27 Apr, 2020
Review #4 received
Received 20 Apr, 2020
Review #2 received
Received 20 Apr, 2020
Reviewer #5 agreed
On 12 Apr, 2020
Reviewer #4 agreed
On 12 Apr, 2020
Reviewers invited
Invitations sent on 09 Apr, 2020
Reviewer #1 agreed
On 09 Apr, 2020
Reviewer #2 agreed
On 09 Apr, 2020
Reviewer #3 agreed
On 09 Apr, 2020
Editor assigned
On 01 Apr, 2020
First submitted
On 31 Mar, 2020
Submission checks complete
On 31 Mar, 2020
Editor invited
On 31 Mar, 2020
Metrics
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PDF Downloads: ...
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Subject Areas
Endocrinology & Metabolism
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This preprint is under consideration at BMC Endocrine Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Relationships between menstrual status and obesity phenotypes in women: a cross-sectional study in northern China
Dong Li
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 2
Posted 28 May, 2020
Published
On 22 Jun, 2020
Published
On 22 Jun, 2020
No community comments so far
Review #1 received
Received 27 May, 2020
Reviewer #1 agreed
On 22 May, 2020
Reviewer #2 agreed
On 22 May, 2020
Reviewers invited
Invitations sent on 21 May, 2020
Editor assigned
On 19 May, 2020
Submission checks complete
On 18 May, 2020
Editor invited
On 18 May, 2020
No comments provided
Review #1 received
Received 27 Apr, 2020
Editorial decision: Major revision
On 27 Apr, 2020
Review #4 received
Received 20 Apr, 2020
Review #2 received
Received 20 Apr, 2020
Reviewer #5 agreed
On 12 Apr, 2020
Reviewer #4 agreed
On 12 Apr, 2020
Reviewers invited
Invitations sent on 09 Apr, 2020
Reviewer #1 agreed
On 09 Apr, 2020
Reviewer #2 agreed
On 09 Apr, 2020
Reviewer #3 agreed
On 09 Apr, 2020
Editor assigned
On 01 Apr, 2020
First submitted
On 31 Mar, 2020
Submission checks complete
On 31 Mar, 2020
Editor invited
On 31 Mar, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Endocrine Disorders.
Background: One of most important concerns of postmenopausal women is obesity. The relationships between menstruation status and obesity phenotypes are unclear. This study aimed to assess the associations between menstrual status and different obesity phenotypes in women.
Methods: In total, 5373 women aged ≥40 years were recruited from the Jidong and Kailuan communities. Basic information was collected via clinical examination, laboratory testing and standardized questionnaires. The women were stratified into the following three groups: menstrual period, menopausal transition period and postmenopausal period. General obesity was defined as a body mass index (BMI) of ≥28 kg/m2. Central obesity was defined as a waist-to-hip ratio (WHR) of >0.85. Visceral obesity was defined as the presence of nonalcoholic fatty liver disease (NAFLD) and increased pericardial fat volume (PFV).
Results: The numbers of women in the menstrual, menopausal transition, and postmenopausal periods were 2807 (52.2%), 675 (12.6%) and 1891 (35.2%), respectively. The adjusted odds ratio (OR) and 95% confidence interval (CI) for central obesity among women in the menopausal transition and postmenopausal periods compared with women in the menstrual period were 1.34 (0.87-2.05) and 0.87 (0.57-1.33), respectively. The OR for NAFLD among postmenopausal women was 1.78 (1.44-2.20). The adjusted β-coefficient (standard error, SE) for PFV among postmenopausal women was 41.25 (7.49). The adjusted OR for general obesity among postmenopausal women was 1.01 (0.77-1.34).
Conclusions: This study demonstrated that menopause is an independent risk factor for central and visceral obesity but not general obesity.
Figure 1
Figure 2
Figure 3
Figure 4