Medical image watermarking represents a promising alternative tool regarding security, digital rights, authenticity and integrity issues. In this paper, an informed medical image watermarking scheme is proposed based on local binary pattern LBP. A watermark is built based on the significant information extracted from the host image by LBP and will be addressed to be embedded through a linear interpolation. Scenarios of geometric and non-geometric attacks have been realized on the watermarked images to evaluate the robustness of the embedded watermark in the extraction process. Furthermore, it is verified through achieved experiments that the proposed scheme is imperceptible and more robust from the achieved results which are very encouraging.