Afghanistan is a country that, suffers with wars and problems related to health issues, and has many shortcomings. Especially in the area of infectious diseases such as measles, corona, paralysis, etc. There are many health challenges in remote areas since the spread of vaccines in this field in Afghanistan. Many groups opposed this process, including religious groups, rural women, clerics and other hidden groups that benefited from this. Therefore, this group talked about the harms of vaccination in mass media, gathered places and made people hesitate not to vaccinate, hence, this has become a challenge. The solution is to cooperate between the cooperating organizations and people who support the vaccine and increasing the level of public awareness of the vaccine, can go through a successful process in Afghanistan. Almost majority of Afghan people are Muslims, and this has played a constructive role in determining the success of vaccination groups, and most of the anti-vaccination movements arise among religious groups. The research conducted in 2017 by Ali Ahmed amid Islamic countries has reached the conclusion that in Islamic countries, parents value moral approvals to vaccinate their children and get fatwas from clerics to vaccinate them, and sometimes the clerics refuse to do it because of disorder. DNA is known and causes its lack of trust among people, which lays the foundation of anti-vaccination movements(Ali ahmad &etl, 201; 154P).