Hypersaline brine production from desalination plants causes huge environmental stress due to the untenable conventional discharge strategies. Particularly, brine production is expected to drastically increase in the coming few decades due to the increasing desalination capacity in attempts of forestalling water scarcity. Thereby, zero liquid discharge (ZLD) is a worth-considering solution for strategic brine management. ZLD or minimal liquid discharge (MLD) systems provide maximum water recovery with least or zero liquid waste generation and valuable salt production. In this work, a theoretical design of ZLD/MLD systems is proposed for RO brine management. Four different scenarios are investigated combining multistage freeze desalination (FD), multistage membrane distillation (MD), and eutectic freeze crystallization (EFC) technologies. Water recovery, water quality, as well as specific energy consumption (SEC) are evaluated. FD experiments showed that ice quality is reduced at greater crystallinity levels and initial concentration. Meanwhile, DCMD module was capable of producing 53 kg/(m2.h) of pure water operating with 69% thermal efficiency. Based on different configuration of the hybrid ZLD system, the proposed design can achieve water recovery between 40% up to 93% with SEC range of 28-114 kWh/m3. Results also showed that the produced water quality is even greater than drinkable water standards (500 mg/l). This work has provided great evidence in the practicality of ZLD/MLD systems for sustainable brine management.