1. Andreu et al. (2019) Clinical Neurophysi- ology | Local corticosteroid injection VS Surgery. Ethic: Reviewed by The Ethics Committee of University Hospital; participants received informed consent. | n = 101 (163 wrists). Women (n = 93) Men (n = 8) Mean age: group A = 50 years, group B = 53 years. Diagnosis: according to NCT. | Group A: OCTR (69 wrists) Group B: local corticosteroid injection If symptoms do not improve after 2 weeks, a second injection is performed (94 wrists). | Symptoms: np-VAS, p-VAS; Functions: f-VAS Neurophysiologic outcomes: NCS parameters. Assessments: baseline and 12 months follow-up. |
2. Demirci et al. (2002) Original article | Local steroid injection VS Surgery Ethic: participants received informed consent. | n = 90 Group A: women (n = 38), Men (n = 6); Group B: women (n = 42), Men (n = 4). Mean age: group A = 48.0 ± 8.4 years, Group B = 45.3 ± 9.9 years. Diagnosis: according to electrophysiologic findings | Group A: OCTR (n = 44); Group B: local steroid injection (n = 46) | Functions: BCTQ (8 items) Symptoms: BCTQ (11 items) Electrophysiologic studies Assessments: baseline, 3 months and 6 months. |
3. Fernand ez-de-las-P ens et al. (2015) Journal of pain | Physical therapy VS Surgery Ethic: approved and reviewed by the Hospital Universitario Fundacion Alcorcon (HUFA); All participants are required to sign informed consents. | n = 120 All participants were women. Mean age: group A = 49 ± 9 years, group B = 47 ± 10 years. Diagnosis: according to clinical and electrophysiologic findings | Group A: OCTR or ECTR (depends on the preferences of the patient and the doctor) (n = 60). Group B: physical therapy (manual therapies) (n = 60) | Pain: NPRS; Function: BCTQ; Symptoms: BCTQ; Self-perceived improvement: GROC Assessments: baseline, 1 months, 3 months, 6 months and 12 months. |
4. Fernand ez-de-las-P ens et al. (2017) European Journal of Pain | Manual therapy VS Surgery Ethic: approved by the local human research committee; All participants are required to sign informed consents. | n = 100 All participants were women. Mean age: group A = 48 ± 9 years, group B = 47 ± 10 years. Diagnosis: according to clinical and electrophysiologic findings | Group A: ECTR (n = 50). Group B: manual therapies (n = 50) | Pressure pain sensitivity: PPTs; Pain: NPRS Assessments: baseline, 3 months, 6 months, 9 months and 12 months |
5. Gerritsen et al. (2002) Jama-Journ al of the American Medical Association | Splinting therapy VS Surgery Ethic: approved by the medical ethics committees. | n = 215 Group A: women (n = 66), Men (n = 21); Group B: women (n = 77), Men (n = 12). Mean age: group A = 49 ± 11 years, Group B = 49 ± 12 years. Diagnosis: according to Electrophysiologi cal criteria | Group A: OCTR (n = 87). Group B: splinting (n = 89) | General improvement: 6-point ordinal transition scale; Symptoms: Symptom Severity Scale (11 questions); Functions: Functional Status Scale (8 items); Overall severity: 11-point numerical rating scale; Neurophysiologic outcomes: NCS. Assessments: baseline, 3 months, 6 months,12 months and 18 months. |
6. Hui et al. (2015) Neurology | Local steroid injection VS Surgery Ethic: Approved by institutional ethics committee; all participants signed informed consent forms | n = 50 Group A: women (n = 24), Men (n = 1); Group B: women (n = 24), Men (n = 1). Mean age: group A = 50.8 ± 11.6 years, Group B = 48.2 ± 6.5 years. Diagnosis; according to electrophysiological criteria | Group A: OCTR (n = 25). Group B: steroid injection (n = 25) | Symptoms: GSS; grip strength assessment; neurophysiologic outcomes: DML and SNCV Assessments: baseline, 6 weeks, 20 weeks. |
7. Jarvik et al. (2009) Lancet | Non-surgical treatments VS Surgery Ethic: Approved by Institutional Review Boards; all participants signed informed consent forms | n = 116 Group A: women (n = 28), Men (n = 29); Group B: women (n = 34), Men (n = 25). Mean age: group A = 50.2 ± 10.3 years, Group B = 51.2 ± 8.9 years. Diagnosis; according to electrodiagnostic tests | Group A: OCTR or ECTR (According to the preference surgeons) (n = 57). Group B: non-steroidal anti-inflammatory Drugs and hand therapy sessions (n = 59) | Functions: the functional status scale of the CASAQ (9 items) Symptoms: the symptom severity scale of the CTSAQ (11 items). Assessments: baseline, 3 months, 6 months, 9 months and 12 months. |
8. Ly-Pen et al. (2005) Arthritis and Rheumatim | Local steroid injection VS Surgery Ethic: Reviewed and approved by the Ethics Committee of the University Hospital Ramo´n y Cajal; all participants received informed consent forms. | n = 101 (163 wrists) women (n = 93), Men (n = 8). Mean age: group A = 50.52 ± 10.87 years, Group B = 53.17± 13.93 years. Diagnosis; according to electrodiagnostic criteria. | Group A: OCTR (80 wrists). Group B: local steroid injection (83 wrists). | Functions and symptoms: VAS Assessments: baseline, 3 months, 6 months and 12 months. |
9. Ly-Pen et al. (2012) Rheumatoly (Oxford) | Local steroid injection VS Surgery Ethic: Reviewed and approved by the Ethic Committee of Hospital Ramo´ n y Cajal; all participants received informed consent forms | n = 101 (163 wrists) women (n = 93), Men (n = 8). Mean age: group A = 50 ± 10years, Group B = 53 ± 14 years. Diagnosis: according to electrodiagnostic criteria. | Group A: OCTR (80 wrists). Group B: local steroid injection (83 wrists) | Functions and symptoms: VAS Assessments: baseline, 3 months, 6 months, 12 months and 24 months. |
10. Ucan et al. (2006) Rheumatolo gy International | Splinting VS Splinting plus local steroid injection VS Surgery | n = 57 Mean age: group A = 44.50 ± 7.24 years, Group B = 44.46± 8.52 years, Group C = 45.27± 13.19 years. Diagnosis; according to electromyogram. | Group A: Splinting (n = 23). Group B: Splinting plus local steroid injection (n = 23). Group C: OCTR (n = 11). | Electromyogram parameters, Functions: Boston Questionnaire (8 items); Symptoms: Boston Questionnaire (11 items) Patients’ satisfaction: 5 -points scale Assessments: baseline, 6 weeks, 3 months, 6 months, 9 months and 12 months |