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Short Report
Jan Maláska
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Brno and Masaryk University, Faculty of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6911-2575
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Trials.
Objectives
The primary objective of this study is to test the hypothesis that administration of dexamethasone 20 mg is superior to a 6 mg dose in adult patients with moderate or severe ARDS due to confirmed COVID-19. The secondary objective is to investigate the efficacy and safety of dexamethasone 20 mg versus dexamethasone 6 mg. The exploratory objective of this study is to assess long-term consequences on mortality and quality of life at 180 and 360 days.
Keywords
COVID-19, Randomised controlled trial, protocol, ARDS, dexamethasone, ventilator-free days
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Peer Review Timeline
CURRENT STATUS: Published
Version 1
Posted 16 Feb, 2021
Published
On 01 Mar, 2021
No community comments so far
Editorial decision: Accept
On 08 Feb, 2021
Reviewers invited
Invitations sent on 07 Feb, 2021
Editor invited
On 07 Feb, 2021
Reviews received
Received 07 Feb, 2021
First submitted
On 04 Feb, 2021
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This preprint is under consideration at Trials. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Short Report
Jan Maláska
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Brno and Masaryk University, Faculty of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6911-2575
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 1
Posted 16 Feb, 2021
Published
On 01 Mar, 2021
No community comments so far
Editorial decision: Accept
On 08 Feb, 2021
Reviewers invited
Invitations sent on 07 Feb, 2021
Editor invited
On 07 Feb, 2021
Reviews received
Received 07 Feb, 2021
First submitted
On 04 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Trials.
Objectives
The primary objective of this study is to test the hypothesis that administration of dexamethasone 20 mg is superior to a 6 mg dose in adult patients with moderate or severe ARDS due to confirmed COVID-19. The secondary objective is to investigate the efficacy and safety of dexamethasone 20 mg versus dexamethasone 6 mg. The exploratory objective of this study is to assess long-term consequences on mortality and quality of life at 180 and 360 days.
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