The aim of this study is to evaluate the diagnostic value of different clinical samples from humans such as blood/serum, stool, and urine as compared to the routinely used nasopharyngeal swab samples for the detection of SARS-CoV2 in COVID-19 patients. We followed COVID-19 patients for three weeks and collected samples on three occasions that is, on the day of admission to the hospital (Day zero), after one week (Day-8), and after the second week (Day-15). The data shows that on the day of the admission of the patients, NPS has a 64% positivity rate, followed by stool, urine, and serum, 38%, 18%, and 17%, respectively. And we observed a nearly similar pattern of positivity rate in the subsequent week’s samples.