Chemical compounds have variety of physicochemical, toxicological and pharmacological properties which predict their nature and how they will react. But the study of these properties requires Herculean and laborious experimentation so its alternative, topological indices were invented about 150 years ago. In this research paper, miscellaneous mathematical and computational methods are applied for the calculation of two versions of Randić index and two versions of sum-connectivity index for the subdivision n S(H3BO3), line graph L(H3BO3) and caged chain C(H3BO3) of H3BO3 layer structure.