Funding: This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115902. This joint undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.
Data Availability:
Due to the confidential nature of speech data, we are unable to this data publicly available. Access to the data used for can be made through reasonable requests to the RADAR-CNS consortium and will be subject to local ethics clearances. Please email the corresponding author for details.
Competing Interests
The Authors declare no Competing Financial or Non-Financial Interests.
Acknowledgement:
The RADAR-CNS project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115902. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA (www.imi.europa.eu). This communication reflects the views of the RADAR-CNS consortium and neither IMI nor the European Union and EFPIA are liable for any use that may be made of the information contained herein. The funding body have not been involved in the design of the study, the collection or analysis of data, or the interpretation of data.
Participant recruitment in Amsterdam was partially accomplished through Hersenonderzoek.nl, a Dutch online registry that facilitates participant recruitment for neuroscience studies (https://hersenonderzoek.nl/). Hersenonderzoek.nl is funded by ZonMw-Memorabel (project no 73305095003), a project in the context of the Dutch Deltaplan Dementie, Gieskes-Strijbis Foundation, the Alzheimer's Society in the Netherlands and Brain Foundation Netherlands Participants in Spain were recruited through the following institutions: Parc Sanitari Sant Joan de Déu network of mental health services (Barcelona); Institut Català de la Salut primary care services (Barcelona); Institut Pere Mata-Mental Health Care (Tarrassa); Hospital Clínico San Carlos (Madrid). This paper represents independent research part funded by the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.
We thank all the members of the RADAR-CNS patient advisory board for their contribution to the device selection procedures, and their invaluable advice throughout the study protocol design. This research was reviewed by a team with experience of mental health problems and their carers who have been specially trained to advise on research proposals and documentation through the Feasibility and Acceptability Support Team for Researchers (FAST-R): a free, confidential service in England provided by the National Institute for Health Research Maudsley Biomedical Research Centre via King’s College London and South London and Maudsley NHS Foundation Trust.
We thank all GLAD Study volunteers for their participation, and gratefully acknowledge the NIHR BioResource, NIHR BioResource centres, NHS Trusts and staff for their contribution. We also acknowledge NIHR BRC, King's College London, South London and Maudsley NHS Trust and King's Health Partners. We thank the National Institute for Health Research, NHS Blood and Transplant, and Health Data Research UK as part of the Digital Innovation Hub Programme.
We thank our colleagues both within the RADAR-CNS consortium and across all involved institutions for their contribution to the development of this protocol. We thank all the members of the RADAR-CNS patient advisory board for their contribution to the device selection procedures, and their invaluable advice throughout the study protocol design.
Author Contributions
NC: Conceptualization, Methodology, Formal Analysis, Writing Original Draft; JD: Conceptualization, Methodology, Data Curation, Writing – Original Draft; PC: Data Curation, Software; FM: Conceptualization, Methodology, Project administration, Writing – Review; SS and FL: Data Curation, Project administration, Writing – Review; EC: Methodology, Validation, Writing – Review; GL, DL, KW, CO: Data Curation, Writing – Review; ELC: Investigation; SS, SB: Conceptualization, Writing – Review; JMH: Project administration, Funding acquisition; BP: Writing – Review, YR, ZR, CS: Software, AF: Software, Project administration, Writing – Review; RB: Project administration, Writing – Review; BS: Project administration, Funding acquisition, Writing – Review; TW: Conceptualization, Project administration, Funding acquisition, Writing – Review; SV: Methodology, Project administration, Writing – Review; RB: Methodology, Software, Project administration, Funding acquisition, Writing – Review; VN: Project administration, Funding acquisition, Writing – Review; MH: Methodology, Project administration, Funding acquisition, Writing – Review.