This preprint is under consideration at BMC Gastroenterology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Evaluation of four scoring systems in prognostication of acute pancreatitis for elderly patients
Yajie Li
Southeast University Zhongda Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2121-6057
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives : To evaluate the four scoring systems, including Ranson, BISAP, Glasgow, and APACHE II in the prognostic assessment of acute pancreatitis (AP) for elderly patients.
Methods: A retrospective study of 918 patients presenting with AP was done at Zhongda Hospital Southeast University, from January 2015 to December 2018. The patients were divided into two groups: 368 patients who were ≥60 years old, and 550 patients who were <60 years old. Four scoring systems were used to analyze all patients.
Results: The severity of the disease, and mortality are significantly different between the two groups (p-value <0.05), while the difference between the two groups about pancreatic necrosis is statistically insignificant (p-value =0.399). The differences of the AUCs (Area under curves) in prognostication of SAP (severe acute pancreatitis) between the two groups are statistically significant (p-value <0.05) for Ranson and APACHE II, while for BISAP and Glasgow, the differences are statistically insignificant. All the four scoring systems are effective and similar in prediction of pancreatic necrosis and death for both groups.
Conclusions: Prediction of severity, pancreatic necrosis and death in AP for elderly patients can be performed very well by using BISAP. APACHE II is more suitable for younger patients when dealing with severity. Ranson and Glasgow can be used to evaluate all AP patients in most cases, however, Ranson is more effective for younger patients when used to assess severity.
Keywords
Acute pancreatitis; elderly patients; prediction; scoring system; ROC (receiver operating characteristic) curve
Figure 1
Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF.
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 14 Apr, 2020
No community comments so far
Editorial decision: Major revision
On 04 May, 2020
Review #2 received
Received 02 May, 2020
Review #1 received
Received 02 May, 2020
Reviewer #2 agreed
On 01 May, 2020
Reviewer #1 agreed
On 29 Apr, 2020
Reviewers invited
Invitations sent on 29 Apr, 2020
Editor assigned
On 13 Apr, 2020
Submission checks complete
On 10 Apr, 2020
Editor invited
On 09 Apr, 2020
First submitted
On 07 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
Learn more about our company.
This preprint is under consideration at BMC Gastroenterology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Evaluation of four scoring systems in prognostication of acute pancreatitis for elderly patients
Yajie Li
Southeast University Zhongda Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2121-6057
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 14 Apr, 2020
No community comments so far
Editorial decision: Major revision
On 04 May, 2020
Review #2 received
Received 02 May, 2020
Review #1 received
Received 02 May, 2020
Reviewer #2 agreed
On 01 May, 2020
Reviewer #1 agreed
On 29 Apr, 2020
Reviewers invited
Invitations sent on 29 Apr, 2020
Editor assigned
On 13 Apr, 2020
Submission checks complete
On 10 Apr, 2020
Editor invited
On 09 Apr, 2020
First submitted
On 07 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives : To evaluate the four scoring systems, including Ranson, BISAP, Glasgow, and APACHE II in the prognostic assessment of acute pancreatitis (AP) for elderly patients.
Methods: A retrospective study of 918 patients presenting with AP was done at Zhongda Hospital Southeast University, from January 2015 to December 2018. The patients were divided into two groups: 368 patients who were ≥60 years old, and 550 patients who were <60 years old. Four scoring systems were used to analyze all patients.
Results: The severity of the disease, and mortality are significantly different between the two groups (p-value <0.05), while the difference between the two groups about pancreatic necrosis is statistically insignificant (p-value =0.399). The differences of the AUCs (Area under curves) in prognostication of SAP (severe acute pancreatitis) between the two groups are statistically significant (p-value <0.05) for Ranson and APACHE II, while for BISAP and Glasgow, the differences are statistically insignificant. All the four scoring systems are effective and similar in prediction of pancreatic necrosis and death for both groups.
Conclusions: Prediction of severity, pancreatic necrosis and death in AP for elderly patients can be performed very well by using BISAP. APACHE II is more suitable for younger patients when dealing with severity. Ranson and Glasgow can be used to evaluate all AP patients in most cases, however, Ranson is more effective for younger patients when used to assess severity.
Figure 1
Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF.