Table 1
Demographic characteristics and medical history of patients at diagnosis: patients were grouped as permanent CH (PCH; n=333) or transient CH (TCH; n=24). Variables are presented as median and interquartile range (table 1A) or frequency of occurrence (%; table 1B)
Table 1A
|
|
|
PCH
|
|
|
TCH
|
|
Variable
|
n
|
Median
|
Interquartile range
|
n
|
Median
|
Interquartile range
|
p
|
Weeks of gestation
|
333
|
40
|
38-41
|
24
|
40
|
37-40
|
1.0
|
Birth weight (g)
|
325
|
3420
|
3060-3800
|
22
|
3380
|
2920-3850
|
1.0
|
APGAR-Score
|
326
|
10
|
7-10
|
22
|
10
|
9-10
|
1.0
|
BMI (kg/m2) after 2 yrs.
|
301
|
16.6
|
15.6-17.5
|
22
|
16
|
14.7-16.5
|
0.8
|
BMI-SDS after 2 yrs.
|
301
|
0.4
|
0.3-1.0
|
22
|
0.0
|
-1.1-0.4
|
0.7
|
Height-SDS after 2 yrs.
|
301
|
0.1
|
-0.6-0.8
|
23
|
0.0
|
-0.6-0.5
|
1.0
|
Table 1B
|
PCH
|
TCH
|
Variable
|
n
|
Prevalence (%)
|
|
n
|
Prevalence (%)
|
|
p
|
Weeks of gestation < 36
|
322
|
5.6
|
-
|
24
|
12.5
|
-
|
1.0
|
Male gender
|
333
|
35.1
|
-
|
24
|
50
|
-
|
1.0
|
Trisomy 21
|
333
|
1.2
|
-
|
24
|
4.2
|
-
|
1.0
|
Dopamine therapy
|
333
|
0.9
|
-
|
24
|
8.3
|
-
|
0.07
|
ATD in pregnancy
|
101
|
2
|
-
|
11
|
18.2
|
-
|
0.1
|
L-T4 withdrawal period
|
211
|
52.6
|
-
|
24
|
100
|
-
|
<0.01
|
L-T4 withdrawal period a./o. L-T4dosage increase
|
333
|
95.2
|
-
|
24
|
100
|
-
|
1.0
|
Developmental test: normal
|
141
|
89
|
-
|
8
|
100
|
-
|
1.0
|
Table 2
Screening TSH (mU/L), confirmation serum TSH (µU/ml), and serum fT4 (ng/ml), dosages of L-T4 at diagnosis, at the age of 1 and 2 years in patients with permanent CH (PCH, n=273) and transient CH (TCH, n=23). Data are given as median with interquartile range, p<0.05 was considered significantly different by chi χ2-test.
|
PCH
|
TCH
|
|
Variable
|
n
|
Median
|
Interquartile range
|
n
|
Median
|
Interquartile range
|
p
|
Screening TSH (mU/L)
|
333
|
150
|
62-237
|
24
|
55.8
|
32.5-136
|
0.06
|
Confirmation TSH (µU/ml)
|
257
|
118
|
62-227
|
23
|
100
|
42-169
|
1.0
|
Serum fT4 (ng/dl)
|
275
|
1.16
|
0.5-2.33
|
21
|
0.96
|
0,4-1.4
|
1.0
|
L-T4 dose at diagnosis (µg)
|
333
|
50
|
44-50
|
24
|
50
|
29-50
|
1.0
|
L-T4 dose at diagnosis (µg/kg)
|
328
|
13.2
|
10-15
|
23
|
12.5
|
10-14
|
1.0
|
L-T4 dose after 6 month (µg)
|
157
|
38
|
30-50
|
13
|
25
|
25-38
|
0.4
|
L-T4 dose after 6 month (µg/kg)
|
153
|
4.74
|
3.8-5.76
|
13
|
4.47
|
3.25-5
|
1.0
|
L-T4 dose after 1 year (µg)
|
307
|
45
|
38-50
|
24
|
30
|
25-42
|
<0.01
|
L-T4 dose after 1 year (µg/kg)
|
306
|
4.52
|
3.8-5.2
|
24
|
2.96
|
2.3-4.6
|
<0.01
|
L-T4 dose after 2 years (µg)
|
302
|
50
|
44-60
|
23
|
37
|
25-50
|
<0.01
|
L-T4 dose after 2 years (µg/kg)
|
301
|
4.03
|
3.6-4.74
|
22
|
2.5
|
1.95-3.66
|
<0.01
|
Table 3
Subgroup analyses in patients with screening-TSH<73mU/L (n=109) Screening TSH (mU/L) at the age of 1 and 2 years in patients with permanent CH (PCH, n=94) and transient CH (TCH, n=15).
|
PCH
|
TCH
|
|
Variable
|
n
|
Median
|
Interquartile range
|
n
|
Median
|
Interquartile range
|
p
|
L-T4 dose after 6 month (µg)
|
45
|
35
|
25-38
|
10
|
25
|
25-35
|
0.35
|
L-T4 dose after 6 month (µg/kg)
|
45
|
4.1
|
3.4-5.4
|
10
|
3.6
|
3.2-4.5
|
0.5
|
L-T4 dose after 1 year (µg)
|
86
|
40
|
37-50
|
15
|
25
|
25-44
|
0.02
|
L-T4 dose after 1 year (µg/kg)
|
86
|
4.4
|
3.5-5.2
|
15
|
2.8
|
2.3-4.9
|
0.04
|
L-T4 dose after 2 year (µg)
|
82
|
50
|
38-50
|
14
|
25
|
25-40
|
<0.01
|
L-T4 dose after 2 year (µg/kg)
|
82
|
3.9
|
3.2-4.3
|
14
|
2.3
|
1.95-3.7
|
0.01
|
L-T4withdrawal period a./o.
L-T4 dosage increase
|
94
|
94
|
-
|
15
|
100
|
-
|
0.5
|
Table 3A/B
Cut-off-concentrations predicting TCH by screening TSH, of dosages of L-T4 at the ages of 1 and 2 years (3A), Subgroup analyses in patients with screening-TSH<73mU/L (PCH n=94, TCH n=15) (3B).
Table 3A
|
Cut-off
|
Sensitivity %
|
Specificity %
|
Screening TSH
|
73mU/L
|
72
|
63
|
L-T4 after 1 y. µg/kg/d
|
3.1
|
90
|
63
|
µg/d
|
36
|
85
|
54
|
L-T4 after 1 y. µg/kg/d
|
2.0
|
99
|
4
|
|
20
|
99
|
8
|
L-T4 after 1 y. µg/kg/d
|
6.3
|
4
|
96
|
µg/d
|
60
|
10
|
96
|
L-T4 after 2 y. µg/kg/d
|
2.95
|
91
|
59
|
µg/d
|
40
|
84
|
65
|
L-T4 after 2 y. µg/kg/d
|
2.0
|
99
|
27
|
µg/d
|
25
|
100
|
13
|
L-T4 after 2 y. µg/kg/d
|
5.0
|
18
|
96
|
µg/d
|
55
|
31
|
96
|
Table 3B
|
Cut-off
|
Sensitivity %
|
Specificity%
|
L-T4 after 1 y. µg/kg/d
|
2.9
|
85
|
60
|
µg/d
|
27.5
|
86
|
60
|
L-T4 after 1 y. µg/kg/d
|
2.2
|
99
|
13
|
µg/d
|
20
|
99
|
7
|
L-T4 after 1 y. µg/kg/d
|
6.6
|
2
|
93
|
µg/d
|
60
|
8
|
100
|
L-T4 after 2 y. µg/kg/d
|
2.96
|
81
|
71
|
|
38
|
83
|
64
|
L-T4 after 2 y. µg/kg/d
|
1.85
|
99
|
21
|
µg/d
|
25
|
99
|
7
|
L-T4 after 2 y. µg/kg/d
|
6.3
|
11
|
100
|
µg/d
|
72.5
|
18
|
100
|