The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the Grading of Cerebral Gliomas: A Meta-Analysis
Objective: To perform quantitative analysis on the efficacy of using relative cerebral blood flow (rCBF) in arterial spin labeling (ASL), relative cerebral blood volume (rCBV) in dynamic magnetic sensitivity contrast-enhanced magnetic resonance imaging (DSC-MRI), and mean kurtosis (MK) in diffusion kurtosis imaging (DKI) to grade cerebral gliomas.
Methods: Literature regarding ASL, DSC-MRI, or DKI in cerebral gliomas grading in both English and Chinese were searched from PubMed, Embase, Web of Science, CBM, China National Knowledge Infrastructure (CNKI), and Wanfang Database as of 2019. A meta-analysis was performed to evaluate the efficacy of ASL, DSC-MRI, and DKI in the grading of cerebral gliomas.
Result: A total of 54 articles (11 in Chinese and 43 in English) were included. Three quantitative parameters in the grading of cerebral gliomas, rCBF in ASL, rCBV in DSC-MRI, and MK in DKI had the pooled sensitivity of 0.88 [95%CI (0.83,0.92)], 0.92 [95%CI (0.83,0.96)], 0.88 [95%CI (0.82,0.92)], and the pooled specificity of 0.91 [95%CI (0.84,0.94)], 0.81 [95%CI (0.73,0.88)], 0.86 [95%CI (0.78,0.91)] respectively. The pooled area under the curve (AUC) were 0.95 [95%CI (0.93,0.97)], 0.91 [95%CI (0.89,0.94)], 0.93 [95%CI (0.91,0.95)] respectively.
Conclusion: Quantitative parameters rCBF, rCBV and MK have high diagnostic accuracy for preoperative grading of cerebral gliomas.
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Posted 14 Aug, 2020
On 24 Aug, 2020
On 11 Aug, 2020
On 10 Aug, 2020
On 09 Aug, 2020
On 09 Aug, 2020
On 30 Jul, 2020
Received 28 Jul, 2020
On 20 Jul, 2020
Invitations sent on 25 Jun, 2020
On 25 Jun, 2020
Received 25 Jun, 2020
On 23 Jun, 2020
On 22 Jun, 2020
On 22 Jun, 2020
On 27 May, 2020
Received 21 May, 2020
On 12 May, 2020
Received 10 May, 2020
On 26 Apr, 2020
Invitations sent on 23 Apr, 2020
On 16 Apr, 2020
On 16 Apr, 2020
On 15 Apr, 2020
On 15 Apr, 2020
The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the Grading of Cerebral Gliomas: A Meta-Analysis
Posted 14 Aug, 2020
On 24 Aug, 2020
On 11 Aug, 2020
On 10 Aug, 2020
On 09 Aug, 2020
On 09 Aug, 2020
On 30 Jul, 2020
Received 28 Jul, 2020
On 20 Jul, 2020
Invitations sent on 25 Jun, 2020
On 25 Jun, 2020
Received 25 Jun, 2020
On 23 Jun, 2020
On 22 Jun, 2020
On 22 Jun, 2020
On 27 May, 2020
Received 21 May, 2020
On 12 May, 2020
Received 10 May, 2020
On 26 Apr, 2020
Invitations sent on 23 Apr, 2020
On 16 Apr, 2020
On 16 Apr, 2020
On 15 Apr, 2020
On 15 Apr, 2020
Objective: To perform quantitative analysis on the efficacy of using relative cerebral blood flow (rCBF) in arterial spin labeling (ASL), relative cerebral blood volume (rCBV) in dynamic magnetic sensitivity contrast-enhanced magnetic resonance imaging (DSC-MRI), and mean kurtosis (MK) in diffusion kurtosis imaging (DKI) to grade cerebral gliomas.
Methods: Literature regarding ASL, DSC-MRI, or DKI in cerebral gliomas grading in both English and Chinese were searched from PubMed, Embase, Web of Science, CBM, China National Knowledge Infrastructure (CNKI), and Wanfang Database as of 2019. A meta-analysis was performed to evaluate the efficacy of ASL, DSC-MRI, and DKI in the grading of cerebral gliomas.
Result: A total of 54 articles (11 in Chinese and 43 in English) were included. Three quantitative parameters in the grading of cerebral gliomas, rCBF in ASL, rCBV in DSC-MRI, and MK in DKI had the pooled sensitivity of 0.88 [95%CI (0.83,0.92)], 0.92 [95%CI (0.83,0.96)], 0.88 [95%CI (0.82,0.92)], and the pooled specificity of 0.91 [95%CI (0.84,0.94)], 0.81 [95%CI (0.73,0.88)], 0.86 [95%CI (0.78,0.91)] respectively. The pooled area under the curve (AUC) were 0.95 [95%CI (0.93,0.97)], 0.91 [95%CI (0.89,0.94)], 0.93 [95%CI (0.91,0.95)] respectively.
Conclusion: Quantitative parameters rCBF, rCBV and MK have high diagnostic accuracy for preoperative grading of cerebral gliomas.
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