The objective of this research is to experimentally evaluate the anaerobic co-digestion of slaughterhouse residues in the city of Guaranda with straw residues from agriculture, such as: amaranth, quinoa and wheat. The study was carried out on a laboratory scale using 311 ml biodigesters under mesophilic conditions of 37°C. Anaerobic co-digestion resulted in methane yields of 407 ml CH4/g VS, with a methane content in the biogas of 77% for the mixture of slaughterhouse waste and quinoa (RM-QU (25:75)). The increase in inoculum in the mixtures composed of slaughterhouse residues and quinoa increased the biodegradability between 17 and 22%. However, in the mixtures of slaughterhouse waste and amaranth (RM-AM (0:100)), a further increase in inoculum decreased biodegradability by 5%. To predict and simulate methane production, 5 kinetic models were used: modified Gompertz, logistic equation, transfer, cone and Richards. The cone model was the one that best adjusted the experimental values with those predicted with an R2 of 0.982 to 0.999 and RMSE of 0.61 to 6.92 ml CH4/g VS. The calculation of the theoretical yield was carried out by stoichiometry and elemental analysis of the samples. Theoretical yields ranged between 480–564 ml CH4/g VS for all mixtures of RM with agricultural residues.