Effect of caudal ketamine on minimum local anesthetic concentration of ropivacaine in children: A prospective randomized trial
Background: Caudal ketamine has been shown to provide an effective and prolonged post-operative analgesia with few adverse effects. However, the effect of caudal ketamine on the minimum local anesthetic concentration (MLAC) of ropivacaine for intra-operative analgesia is unclear.
Methods: One hundred and sixty-nine children were randomized to five groups: Group C (caudal ropivacaine only), Group K 0.25 (caudal ropivacaine plus 0.25 mg/kg ketamine), Group K 0.5 (caudal ropivacaine plus 0.5 mg/kg ketamine), Group K 0.75 (caudal ropivacaine plus 0.75 mg/kg ketamine), and Group K 1.0 (caudal ropivacaine plus 1.0 mg/kg ketamine). The primary outcome was the MLAC values of ropivacaine with/without ketamine for caudal block.
Results: The MLAC values of ropivacaine were 0.128% (0.028%) in the control group, 0.112% (0.021%) in Group K 0.25 , 0.112% (0.018%) in Group K 0.5 , 0.110% (0.019%) in Group K 0.75 , and 0.110% (0.020%) in Group K 1.0 . There were no significant differences among the five groups for the MLAC values (p=0.11). During the post-operative period the mean durations of analgesia were 270, 381, 430, 494, and 591 min in the control, K 0.25 , K 0. 5 , K 0.75 , and K 1.0 groups respectively, which shown significant differences among the five groups (p<0.05).
Conclusions: Adding caudal ketamine to ropivacaine prolong the duration of post-operative analgesia; however, it does not decrease the MLAC of caudal ropivacaine for intra-operative analgesia in children.
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Posted 02 Jan, 2020
On 27 Mar, 2020
Received 08 Jan, 2020
Invitations sent on 03 Jan, 2020
On 03 Jan, 2020
On 26 Dec, 2019
On 25 Dec, 2019
On 25 Dec, 2019
On 26 Nov, 2019
Received 25 Nov, 2019
On 20 Nov, 2019
Received 03 Sep, 2019
On 28 Aug, 2019
Invitations sent on 02 Aug, 2019
On 18 Jul, 2019
On 11 Jul, 2019
On 11 Jul, 2019
On 02 Jul, 2019
Effect of caudal ketamine on minimum local anesthetic concentration of ropivacaine in children: A prospective randomized trial
Posted 02 Jan, 2020
On 27 Mar, 2020
Received 08 Jan, 2020
Invitations sent on 03 Jan, 2020
On 03 Jan, 2020
On 26 Dec, 2019
On 25 Dec, 2019
On 25 Dec, 2019
On 26 Nov, 2019
Received 25 Nov, 2019
On 20 Nov, 2019
Received 03 Sep, 2019
On 28 Aug, 2019
Invitations sent on 02 Aug, 2019
On 18 Jul, 2019
On 11 Jul, 2019
On 11 Jul, 2019
On 02 Jul, 2019
Background: Caudal ketamine has been shown to provide an effective and prolonged post-operative analgesia with few adverse effects. However, the effect of caudal ketamine on the minimum local anesthetic concentration (MLAC) of ropivacaine for intra-operative analgesia is unclear.
Methods: One hundred and sixty-nine children were randomized to five groups: Group C (caudal ropivacaine only), Group K 0.25 (caudal ropivacaine plus 0.25 mg/kg ketamine), Group K 0.5 (caudal ropivacaine plus 0.5 mg/kg ketamine), Group K 0.75 (caudal ropivacaine plus 0.75 mg/kg ketamine), and Group K 1.0 (caudal ropivacaine plus 1.0 mg/kg ketamine). The primary outcome was the MLAC values of ropivacaine with/without ketamine for caudal block.
Results: The MLAC values of ropivacaine were 0.128% (0.028%) in the control group, 0.112% (0.021%) in Group K 0.25 , 0.112% (0.018%) in Group K 0.5 , 0.110% (0.019%) in Group K 0.75 , and 0.110% (0.020%) in Group K 1.0 . There were no significant differences among the five groups for the MLAC values (p=0.11). During the post-operative period the mean durations of analgesia were 270, 381, 430, 494, and 591 min in the control, K 0.25 , K 0. 5 , K 0.75 , and K 1.0 groups respectively, which shown significant differences among the five groups (p<0.05).
Conclusions: Adding caudal ketamine to ropivacaine prolong the duration of post-operative analgesia; however, it does not decrease the MLAC of caudal ropivacaine for intra-operative analgesia in children.
Figure 1
Figure 2
Figure 3