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Research
Praeruptorin C alleviates cognitive impairment in Type 2 diabetic mice through restoring PI3K/AKT/ GSK3β pathway
Le Yang
Xi'an Tangdu Hospital of No4 Military Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1706-5241
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This work is licensed under a CC BY 4.0 License. Read Full License
Diabetic encephalopathy is a common complication of diabetes, leading to cognitive impairment. In this study, we investigated the therapeutic effects of Praeruptorin C (Pra-C), an active component of traditional Chinese herb medicine Peucedanum praeruptorum, on cognitive impairment in a mouse model of type 2 diabetes. Our results showed that Pra-C administration significantly reduced body weight and fasting blood glucose levels, relieved learning and memory behavioral deficits in diabetic model mice. The effects of Pra-C on learning and memory ability were further confirmed by late-phase LTP (L-LTP) facilitation, which was recorded by Med64 electrophysiology recording system. Pra-C also restored the activation of PI3K/AKT/GSK3β signaling pathway in hippocampus of mice suffering from diabetes. Taken together, this study demonstrates that Pra-C alleviates cognitive impairment in diabetic mice by restoring PI3K/AKT/GSK3β activation.
Keywords
Type 2 diabetes, diabetic encephalopathy, Praeruptorin C, PI3K/AKT/GSK3β, L-LTP
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This is a preprint. It has not completed peer review.
Research
Praeruptorin C alleviates cognitive impairment in Type 2 diabetic mice through restoring PI3K/AKT/ GSK3β pathway
Le Yang
Xi'an Tangdu Hospital of No4 Military Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1706-5241
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 16 Apr, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cellular & Molecular Neuroscience
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Diabetic encephalopathy is a common complication of diabetes, leading to cognitive impairment. In this study, we investigated the therapeutic effects of Praeruptorin C (Pra-C), an active component of traditional Chinese herb medicine Peucedanum praeruptorum, on cognitive impairment in a mouse model of type 2 diabetes. Our results showed that Pra-C administration significantly reduced body weight and fasting blood glucose levels, relieved learning and memory behavioral deficits in diabetic model mice. The effects of Pra-C on learning and memory ability were further confirmed by late-phase LTP (L-LTP) facilitation, which was recorded by Med64 electrophysiology recording system. Pra-C also restored the activation of PI3K/AKT/GSK3β signaling pathway in hippocampus of mice suffering from diabetes. Taken together, this study demonstrates that Pra-C alleviates cognitive impairment in diabetic mice by restoring PI3K/AKT/GSK3β activation.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5