Acknowledgments
The authors acknowledge the dedication and support of the SURBCAN Study Group (in alphabetical order): IMIM (Del Mar Hospital Medical Research Institute), Barcelona: Mercè Abizanda, Xavier Castells, Mercè Comas, Laia Domingo, Talita Duarte, Anna Jansana, Javier Louro, Anna Renom, María Sala. Costa del Sol Hospital, University of Malaga: María del Carmen Martínez, Cristóbal Molina, María del Carmen Padilla, Maximino Redondo. EpiChron Chronic Disease Research Group of the Aragon Health Sciences Institute, Aragon: Antonio Gimeno-Miguel Manuela Lanzuela, Beatriz Poblador-Plou, Alexandra Prados-Torres. Primary Care Research Unit. Primary Care Management, 12 de Octubre University Hospital, Madrid: Ángel Alberquilla, Isabel del Cura, Antonio Díaz, Teresa Sanz, Guillermo Pérez, Ana María Muñoz, Francisco Javier Salamanca, Óscar Toldos. Research Network on Health Services and Chronic Disease of the Miguel Servet Foundation, Navarre: Javier Baquedano, Rossana Burgui, Javier Gorricho, Berta Ibáñez, Conchi Moreno, Ibai Tamayo. This work was supported by Carlos III Health Institute [PI16/00244] and [PI19/00056], by the ERDF (European Regional Development Fund/European Social Fund), and by the Research Network on Health Services and Chronic Disease [RD16/0001/0013].
We thank the research team at the Costa del Sol Hospital for their support
Funding
This work was supported by Carlos III Institute of Health grant numbers 'PI16/00244'/ 'PI15/00098' and by the Research Network on Health Services and Chronic Diseases-REDISSEC grant number 'RD16/0001/0013'.
The project also received a research grant from the Carlos III Institute of Health of the Ministry of Science and Innovation (Spain) awarded on the call for the creation of Health Outcomes-Oriented Cooperative Research Networks (RICORS), with reference RD21/0016/0015, co-funded by European Union– NextGenerationEU funds.
Competing of interests
The authors declare that they have no competing interests.
Contributors
All authors contributed to the study conception and design. Material preparation and data collection were performed by María Padilla-Ruiz, Antonio Gimeno-Miguel, M.ª Carmen Martínez-Casanova, Anna Jansana, Beatriz Poblador-Plou, and Teresa Sanz Cuesta. The analysis and first draft of the manuscript were written by María Padilla-Ruiz, Antonio Gimeno-Miguel, Francisco Rivas-Ruiz, and Maximino Redondo. Alexandra Prados-Torres, Isabel Del Cura, Berta Ibáñez, Xavier Castells, and María Sala contributed in the writing of the later versions of the manuscript. María Sala was the principal investigator (PI) of SURBCAN cohort study and Maximino Redondo was the PI of this study. All authors read and approved the final manuscript.
Ethics statement
This project was carried out in accordance with the basic principles of protection of human rights and dignity, as stated in the Declaration of Helsinki and in accordance with the regulations in force. The Del Mar Hospital Medical Research Institute, as the coordinating center, obtained approval for this study from its ethics committee. This study was approved by the Ethics Committee of Parc de Salut Mar (Catalonia), the Clinical Research Ethics Committee of the Government of Navarre, the Ethics Committee of the Jordi Gol University Institute for Research in Primary Care (Catalonia), the Ethics Committee of the Costa del Sol Health Agency (Andalusia), the Central Research Commission of the Community of Madrid and the Ethics Committee of Aragon.
All information obtained was treated confidentially and anonymously, in compliance with Organic Law 3/2018 of 6 December. The usual care was provided to the study population and there were no changes or action taken regarding treatment or visits and there was no collection or analysis of biological samples. Informed consent from patients was not necessary, as the SURBCAN study is a retrospective observational project that only included anonymized data from clinical and administrative databases.