Cubic Pythagorean fuzzy set is the recent devolvement in fuzzy set theory. The aim of this paper is to propose a series of aggregation operators named Frank operators based on Frank t-norm and t-conorm under cubic Pythagorean fuzzy sets environment. The main objective of these operators is to capture the interrelationship between the arguments. Some basic properties such as monotonicity, boundedness, and commutativity are discussed in detail. Then we develop a decision-making approach based on the stated operators to deal with multi-criteria group decision-making problems. Finally, the application of the proposed method is illustrated with a numerical example. The outcomes of the proposed approach are compared with some existing approaches to illustrate the applicability and feasibility of the proposed approach.