It is recommended that cyanoacrylate tissue glue be used in oral surgery to enhance soft tissue healing and reduce problems (pain, inflammation, and bleeding) related to wound healing. The goal of the study was to examine the healing of skin wounds using vicryl suture (control group) and cyanoacrylate tissue adhesive (study group).The histological results showed that skin specimens of control rabbit stained with hematoxylin and eosin stain two weeks after surgery revealed formation of thin epithelial layer with absence of epithelial ridges associated with degeneration of collagen fibers while the skin of the experimental site revealed increased epithelial thickness with formation of epithelial ridges and increased thickness of collagen fiber. Skin wounds of control site stained with Masson’s trichrome stain revealed mild positive staining reaction of collagen fibers while skin wounds of the experimental site showed strongly positive staining reaction of collagen fibers for Masson’s trichrome stain. The immunohistochemical localization of transforming growth factor beta (TGF-b) revealed that examination of skin specimens of control site showed weak positive staining reaction while skin wounds of the experimental site showed strongly positive staining reaction. Immunohistochemical localization of tumor necrosis factor alpha (TNF-α) showed that examination of skin specimens of control site showed weak to moderate positive staining reaction while skin wounds of the experimental site showed weak positive staining reaction.