[1] J.W.-P. Michael, K.U. Schlüter-Brust, P. Eysel, The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee., Dtsch. Arztebl. Int. 107 (2010) 152–62. https://doi.org/10.3238/arztebl.2010.0152.
[2] Y. Zhang, J.M. Jordan, Epidemiology of osteoarthritis., Clin. Geriatr. Med. 26 (2010) 355–69. https://doi.org/10.1016/j.cger.2010.03.001.
[3] J.A. Buckwalter, C. Saltzman, T. Brown, The impact of osteoarthritis: implications for research., Clin. Orthop. Relat. Res. (2004) S6-15.
[4] A.I. Caplan, Mesenchymal Stem Cells: Time to Change the Name!, Stem Cells Transl. Med. 6 (2017) 1445–1451. https://doi.org/10.1002/sctm.17-0051.
[5] J. Freitag, D. Bates, R. Boyd, K. Shah, A. Barnard, L. Huguenin, A. Tenen, Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review., BMC Musculoskelet. Disord. 17 (2016) 230. https://doi.org/10.1186/s12891-016-1085-9.
[6] Y.-M. Pers, M. Ruiz, D. Noël, C. Jorgensen, Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives., Osteoarthr. Cartil. 23 (2015) 2027–35. https://doi.org/10.1016/j.joca.2015.07.004.
[7] H.I. Pas, M. Winters, H.J. Haisma, M.J. Koenis, J.L. Tol, M.H. Moen, Stem cell injections in knee osteoarthritis: a systematic review of the literature, Br. J. Sports Med. 51 (2017) 1125–1133. https://doi.org/10.1136/bjsports-2016-096793.
[8] J.M. Murphy, D.J. Fink, E.B. Hunziker, F.P. Barry, Stem cell therapy in a caprine model of osteoarthritis., Arthritis Rheum. 48 (2003) 3464–74. https://doi.org/10.1002/art.11365.
[9] S.E. Haynesworth, M.A. Baber, A.I. Caplan, Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha., J. Cell. Physiol. 166 (1996) 585–92. https://doi.org/10.1002/(SICI)1097-4652(199603)166:3<585::AID-JCP13>3.0.CO;2-6.
[10] M. Brittberg, A. Lindahl, A. Nilsson, C. Ohlsson, O. Isaksson, L. Peterson, Treatment of Deep Cartilage Defects in the Knee with Autologous Chondrocyte Transplantation, N. Engl. J. Med. 331 (1994) 889–895. https://doi.org/10.1056/NEJM199410063311401.
[11] G. Knutsen, J.O. Drogset, L. Engebretsen, T. Grøntvedt, V. Isaksen, T.C. Ludvigsen, S. Roberts, E. Solheim, T. Strand, O. Johansen, A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years., J. Bone Joint Surg. Am. 89 (2007) 2105–12. https://doi.org/10.2106/JBJS.G.00003.
[12] T.M. Campbell, S.M. Churchman, A. Gomez, D. McGonagle, P.G. Conaghan, F. Ponchel, E. Jones, Mesenchymal Stem Cell Alterations in Bone Marrow Lesions in Patients With Hip Osteoarthritis, Arthritis Rheumatol. 68 (2016) 1648–1659. https://doi.org/10.1002/art.39622.
[13] M. Sánchez, E. Anitua, D. Delgado, P. Sanchez, R. Prado, J.J. Goiriena, F. Prosper, G. Orive, S. Padilla, A new strategy to tackle severe knee osteoarthritis: Combination of intra-articular and intraosseous injections of Platelet Rich Plasma, Expert Opin. Biol. Ther. 16 (2016) 627–643. https://doi.org/10.1517/14712598.2016.1157162.
[14] S. Grassel, N. Ahmed, Influence of cellular microenvironment and paracrine signals on chondrogenic differentiation, Front. Biosci. 12 (2007) 4946–4956. https://doi.org/10.2741/2440.
[15] I. Sekiya, B.L. Larson, J.T. Vuoristo, R.L. Reger, D.J. Prockop, Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma., Cell Tissue Res. 320 (2005) 269–76. https://doi.org/10.1007/s00441-004-1075-3.
[16] M. Al-Najar, H. Khalil, J. Al-Ajlouni, E. Al-Antary, M. Hamdan, R. Rahmeh, D. Alhattab, O. Samara, M. Yasin, A. Al Abdullah, E. Al-jabbari, D. Hmaid, H. Jafar, A. Awidi, Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: A phase I/II study, J. Orthop. Surg. Res. 12 (2017). https://doi.org/10.1186/s13018-017-0689-6.
[17] R. Bastos, M. Mathias, R. Andrade, R.J.F.C. Amaral, V. Schott, A. Balduino, R. Bastos, J. Miguel Oliveira, R.L. Reis, S. Rodeo, J. Espregueira-Mendes, Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial., Knee Surg. Sports Traumatol. Arthrosc. (2019). https://doi.org/10.1007/s00167-019-05732-8.
[18] J.M. Lamo-Espinosa, G. Mora, J.F. Blanco, F. Granero-Moltó, J.M. Nuñez-Córdoba, C. Sánchez-Echenique, J.M. Bondía, J.D. Aquerreta, E.J. Andreu, E. Ornilla, E.M. Villarón, A. Valentí-Azcárate, F. Sánchez-Guijo, M.C. del Cañizo, J.R. Valentí-Nin, F. Prósper, Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II), J. Transl. Med. 14 (2016) 246. https://doi.org/10.1186/s12967-016-0998-2.
[19] L. Orozco, A. Munar, R. Soler, M. Alberca, F. Soler, M. Huguet, J. Sentís, A. Sánchez, J. García-Sancho, Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells, Transplantation. 97 (2014) e66–e68. https://doi.org/10.1097/TP.0000000000000167.
[20] W.L. Dai, A.G. Zhou, H. Zhang, J. Zhang, Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials, Arthrosc. - J. Arthrosc. Relat. Surg. 33 (2017) 659-670.e1. https://doi.org/10.1016/j.arthro.2016.09.024.
[21] P.A. Smith, Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis, Am. J. Sports Med. 44 (2015) 884–891. https://doi.org/10.1177/0363546515624678.
[22] G. Filardo, E. Kon, M.T. Pereira Ruiz, F. Vaccaro, R. Guitaldi, A. Di Martino, A. Cenacchi, P.M. Fornasari, M. Marcacci, Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: Single- versus double-spinning approach, Knee Surgery, Sport. Traumatol. Arthrosc. 20 (2012) 2082–2091. https://doi.org/10.1007/s00167-011-1837-x.
[23] J. Woodell-May, A. Matuska, M. Oyster, Z. Welch, K. O’Shaughnessey, J. Hoeppner, Autologous protein solution inhibits MMP-13 production by IL-1β and TNFα-stimulated human articular chondrocytes, J. Orthop. Res. 29 (2011) 1320–1326. https://doi.org/10.1002/jor.21384.
[24] X.-B. Tang, P.-L. Dong, J. Wang, H.-Y. Zhou, H.-X. Zhang, S.-Z. Wang, Effect of autologous platelet-rich plasma on the chondrogenic differentiation of rabbit adipose-derived stem cells in vitro., Exp. Ther. Med. 10 (2015) 477–483. https://doi.org/10.3892/etm.2015.2528.
[25] S. Elder, J. Thomason, Effect of Platelet-Rich Plasma on Chondrogenic Differentiation in Three-Dimensional Culture, Open Orthop. J. 8 (2014) 78–84. https://doi.org/10.2174/1874325001408010078.
[26] J.M. Gilbertie, J.M. Long, A.G. Schubert, A.K. Berglund, T.P. Schaer, L. V Schnabel, Pooled Platelet-Rich Plasma Lysate Therapy Increases Synoviocyte Proliferation and Hyaluronic Acid Production While Protecting Chondrocytes From Synoviocyte-Derived Inflammatory Mediators., Front. Vet. Sci. 5 (2018) 150. https://doi.org/10.3389/fvets.2018.00150.
[27] R. Sakata, S.M. Mcnary, K. Miyatake, C.A. Lee, J.M. Van Den Bogaerde, R.A. Marder, A.H. Reddi, Stimulation of the Superficial Zone Protein and Lubrication in the Articular Cartilage by Human Platelet-Rich Plasma, Am. J. Sports Med. 43 (2015) 1467–1473. https://doi.org/10.1177/0363546515575023.
[28] J.M. Lamo-Espinosa, G. Mora, J.F. Blanco, F. Granero-Molt?, J.M. Nu?ez-C?rdoba, C. S?nchez-Echenique, J.M. Bond?a, J.D. Aquerreta, E.J. Andreu, E. Ornilla, E.M. Villar?n, A. Valent?-Azc?rate, F. S?nchez-Guijo, M.C. Ca?izo, J.R. Valent?-Nin, F. Pr?sper, Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: Multicenter randomized controlled clinical trial (phase I/II), J. Transl. Med. 14 (2016). https://doi.org/10.1186/s12967-016-0998-2.
[29] E.C. Huskisson, Measurement of pain., J. Rheumatol. 9 (n.d.) 768–9.
[30] N. Bellamy, Outcome measurement in osteoarthritis clinical trials., J. Rheumatol. Suppl. 43 (1995) 49–51.
[31] A. Escobar, M. Gonzalez, J.M. Quintana, K. Vrotsou, A. Bilbao, C. Herrera-Espiñeira, L. Garcia-Perez, F. Aizpuru, C. Sarasqueta, Patient acceptable symptom state and OMERACT-OARSI set of responder criteria in joint replacement. Identification of cut-off values., Osteoarthr. Cartil. 20 (2012) 87–92. https://doi.org/10.1016/j.joca.2011.11.007.
[32] C.G. Peterfy, A. Guermazi, S. Zaim, P.F.J. Tirman, Y. Miaux, D. White, M. Kothari, Y. Lu, K. Fye, S. Zhao, H.K. Genant, Whole-organ magnetic resonance imaging score (WORMS) of the knee in osteoarthritis, Osteoarthr. Cartil. 12 (2004) 177–190. https://doi.org/10.1016/j.joca.2003.11.003.
[33] J.M. Lamo-Espinosa, G. Mora, J.F. Blanco, F. Granero-Moltó, J.M. Núñez-Córdoba, S. López-Elío, E. Andreu, F. Sánchez-Guijo, J.D. Aquerreta, J.M. Bondía, A. Valentí-Azcárate, M. del Consuelo del Cañizo, E.M. Villarón, J.R. Valentí-Nin, F. Prósper, Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II), J. Transl. Med. 16 (2018) 213. https://doi.org/10.1186/s12967-018-1591-7.
[34] C.H. Jo, Y.G. Lee, W.H. Shin, H. Kim, J.W. Chai, E.C. Jeong, J.E. Kim, H. Shim, J.S. Shin, I.S. Shin, J.C. Ra, S. Oh, K.S. Yoon, Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial., Stem Cells. 32 (2014) 1254–66. https://doi.org/10.1002/stem.1634.
[35] D. Fang, P. Jin, Q. Huang, Y. Yang, J. Zhao, L. Zheng, Platelet-rich plasma promotes the regeneration of cartilage engineered by mesenchymal stem cells and collagen hydrogel via the TGF-β/SMAD signaling pathway., J. Cell. Physiol. 234 (2019) 15627–15637. https://doi.org/10.1002/jcp.28211.
[36] A. Drengk, A. Zapf, E.K. Stürmer, K.M. Stürmer, K.H. Frosch, Influence of platelet-rich plasma on chondrogenic differentiation and proliferation of chondrocytes and mesenchymal stem cells, Cells Tissues Organs. 189 (2009) 317–326. https://doi.org/10.1159/000151290.
[37] R. Bastos, M. Mathias, R. Andrade, R. Bastos, A. Balduino, V. Schott, S. Rodeo, J. Espregueira-Mendes, Intra-articular injections of expanded mesenchymal stem cells with and without addition of platelet-rich plasma are safe and effective for knee osteoarthritis., Knee Surg. Sports Traumatol. Arthrosc. 26 (2018) 3342–3350. https://doi.org/10.1007/s00167-018-4883-9.
[38] J.W. Belk, M.J. Kraeutler, D.A. Houck, J.A. Goodrich, J.L. Dragoo, E.C. McCarty, Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials, Am. J. Sports Med. (2020). https://doi.org/10.1177/0363546520909397.
[39] Z. Xu, W. Yin, Y. Zhang, X. Qi, Y. Chen, X. Xie, C. Zhang, Comparative evaluation of leukocyte-and platelet-rich plasma and pure platelet-rich plasma for cartilage regeneration, Sci. Rep. 7 (2017). https://doi.org/10.1038/srep43301.
[40] E. Anitua, R. Prado, G. Orive, Safety and efficient ex vivo expansion of stem cells using platelet-rich plasma technology, Ther. Deliv. 4 (2013) 1163–1177. https://doi.org/10.4155/tde.13.68.
[41] R.C. Dregalla, Y. Uribe, M. Bodor, Human mesenchymal stem cells respond differentially to platelet preparations and synthesize hyaluronic acid in nucleus pulposus extracellular matrix, Spine J. (2020). https://doi.org/10.1016/j.spinee.2020.06.011.
[42] J.M. Vilar, M. Morales, A. Santana, G. Spinella, M. Rubio, B. Cuervo, R. Cugat, J.M. Carrillo, Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs, BMC Vet. Res. 9 (2013). https://doi.org/10.1186/1746-6148-9-131.
[43] A.I. Caplan, J.E. Dennis, Mesenchymal stem cells as trophic mediators., J. Cell. Biochem. 98 (2006) 1076–84. https://doi.org/10.1002/jcb.20886.
[44] G.A. Hawker, S. Mian, T. Kendzerska, M. French, Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF, Arthritis Care Res. 63 (2011). https://doi.org/10.1002/acr.20543.
[45] S. Wandel, P. Jüni, B. Tendal, E. Nüesch, P.M. Villiger, N.J. Welton, S. Reichenbach, S. Trelle, Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: Network meta-analysis, BMJ. 341 (2010) 711. https://doi.org/10.1136/bmj.c4675.
[46] B.M. Saltzman, T. Leroux, M.A. Meyer, B.A. Basques, J. Chahal, B.R. Bach, A.B. Yanke, B.J. Cole, The Therapeutic Effect of Intra-articular Normal Saline Injections for Knee Osteoarthritis., Am. J. Sports Med. (2016) 363546516680607. https://doi.org/10.1177/0363546516680607.
[47] A. Vega, M.A. Martín-Ferrero, F. Del Canto, M. Alberca, V. García, A. Munar, L. Orozco, R. Soler, J.J. Fuertes, M. Huguet, A. Sánchez, J. García-Sancho, Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: A randomized controlled trial, Transplantation. 99 (2015) 1681–1690. https://doi.org/10.1097/TP.0000000000000678.