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Research article
Relationship of chronic endometritis with chronic deciduitis in cases of miscarriage.
Fuminori Kimura
Shiga Ika Daigaku
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9840-4227
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The presence of chronic deciduitis (CD) was determined in patients diagnosed with or without chronic endometritis (CE) before pregnancy.
Objective: To study the effect of CE on decidua in cases of miscarriage.
Methods: Decidual tissue was obtained from the patients who miscarried at the first pregnancy within a year after the diagnosis of the presence or absence of CE. The number and distribution pattern of plasma cells stained with CD138 in decidual tissue in 10 high-power fields (HPFs) was examined. The prevalence of CD diagnosed with four different grade; grade 0, no plasma cell in 10 HPFs, thus Non-CD ;grade 1, rare single plasma cells; grade 2, rare clusters or more than 5 single cells total; and grade 3, many plasma cells with more than 5 clusters, were examined and compared between Non-CE and CE.
Results: The incidence rate of CD of grade2+3 was significantly higher in CE than Non-CE (53.8%; 7/13 vs. 0%; 0/13, P<0.01). Presence of clusters or a number of plasma cells in 10 HPFs of decidua showed a sensitivity of 53.8%, a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 68.4% for the diagnosis of CE.
Conclusion: Presence of clusters of plasma cells or five or more of plasma cells in decidua was found in more than half of CE, but not found in Non-CE. When CD with cluster or five or more of plasma cells is confirmed histologically in miscarriage decidual tissue, the presence of CE before the pregnancy should be suspected.
Keywords
chronic endometritis, chronic deciduitis, miscarriage
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CURRENT STATUS: Under Review
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Posted 26 May, 2020
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Reviewer #1 agreed
On 19 May, 2020
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Reviewer #2 agreed
On 19 May, 2020
Review #2 received
Received 19 May, 2020
Reviewers invited
Invitations sent on 18 May, 2020
Editor assigned
On 14 May, 2020
Submission checks complete
On 13 May, 2020
Editor invited
On 13 May, 2020
No comments provided
Editorial decision: Minor revision
On 05 May, 2020
Review #3 received
Received 30 Apr, 2020
Reviewer #5 agreed
On 30 Apr, 2020
Review #4 received
Received 30 Apr, 2020
Review #5 received
Received 30 Apr, 2020
Reviewer #4 agreed
On 30 Apr, 2020
Reviewer #3 agreed
On 29 Apr, 2020
Review #2 received
Received 12 Apr, 2020
Reviewer #2 agreed
On 09 Apr, 2020
Review #1 received
Received 24 Feb, 2020
Editor assigned
On 08 Feb, 2020
Reviewers invited
Invitations sent on 08 Feb, 2020
Reviewer #1 agreed
On 08 Feb, 2020
Submission checks complete
On 07 Feb, 2020
Editor invited
On 07 Feb, 2020
First submitted
On 17 Jan, 2020
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This preprint is under consideration at BMC Women's Health. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Relationship of chronic endometritis with chronic deciduitis in cases of miscarriage.
Fuminori Kimura
Shiga Ika Daigaku
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9840-4227
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 2
Posted 26 May, 2020
No community comments so far
Reviewer #1 agreed
On 19 May, 2020
Review #1 received
Received 19 May, 2020
Reviewer #2 agreed
On 19 May, 2020
Review #2 received
Received 19 May, 2020
Reviewers invited
Invitations sent on 18 May, 2020
Editor assigned
On 14 May, 2020
Submission checks complete
On 13 May, 2020
Editor invited
On 13 May, 2020
No comments provided
Editorial decision: Minor revision
On 05 May, 2020
Review #3 received
Received 30 Apr, 2020
Reviewer #5 agreed
On 30 Apr, 2020
Review #4 received
Received 30 Apr, 2020
Review #5 received
Received 30 Apr, 2020
Reviewer #4 agreed
On 30 Apr, 2020
Reviewer #3 agreed
On 29 Apr, 2020
Review #2 received
Received 12 Apr, 2020
Reviewer #2 agreed
On 09 Apr, 2020
Review #1 received
Received 24 Feb, 2020
Editor assigned
On 08 Feb, 2020
Reviewers invited
Invitations sent on 08 Feb, 2020
Reviewer #1 agreed
On 08 Feb, 2020
Submission checks complete
On 07 Feb, 2020
Editor invited
On 07 Feb, 2020
First submitted
On 17 Jan, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The presence of chronic deciduitis (CD) was determined in patients diagnosed with or without chronic endometritis (CE) before pregnancy.
Objective: To study the effect of CE on decidua in cases of miscarriage.
Methods: Decidual tissue was obtained from the patients who miscarried at the first pregnancy within a year after the diagnosis of the presence or absence of CE. The number and distribution pattern of plasma cells stained with CD138 in decidual tissue in 10 high-power fields (HPFs) was examined. The prevalence of CD diagnosed with four different grade; grade 0, no plasma cell in 10 HPFs, thus Non-CD ;grade 1, rare single plasma cells; grade 2, rare clusters or more than 5 single cells total; and grade 3, many plasma cells with more than 5 clusters, were examined and compared between Non-CE and CE.
Results: The incidence rate of CD of grade2+3 was significantly higher in CE than Non-CE (53.8%; 7/13 vs. 0%; 0/13, P<0.01). Presence of clusters or a number of plasma cells in 10 HPFs of decidua showed a sensitivity of 53.8%, a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 68.4% for the diagnosis of CE.
Conclusion: Presence of clusters of plasma cells or five or more of plasma cells in decidua was found in more than half of CE, but not found in Non-CE. When CD with cluster or five or more of plasma cells is confirmed histologically in miscarriage decidual tissue, the presence of CE before the pregnancy should be suspected.
Figure 1
Figure 2